Papassotiropoulos, A. (57207584929)A. (57207584929)PapassotiropoulosHenke, K. (7005722592)K. (7005722592)HenkeStefanova, E. (7004567022)E. (7004567022)StefanovaAerni, A. (6507564517)A. (6507564517)AerniMüller, A. (55968044000)A. (55968044000)MüllerDemougin, P. (55925139100)P. (55925139100)DemouginVogler, C. (24074940400)C. (24074940400)VoglerSigmund, J.C. (24075056200)J.C. (24075056200)SigmundGschwind, L. (24381604600)L. (24381604600)GschwindHuynh, K.-D. (8574293800)K.-D. (8574293800)HuynhColuccia, D. (8574293500)D. (8574293500)ColucciaMondadori, C.R. (8736775500)C.R. (8736775500)MondadoriHänggi, J. (12243647500)J. (12243647500)HänggiBuchmann, A. (15043794200)A. (15043794200)BuchmannKostic, V. (35239923400)V. (35239923400)KosticNovakovic, I. (6603235567)I. (6603235567)NovakovicVan Den Bussche, H. (57060063100)H. (57060063100)Van Den BusscheKaduszkiewicz, H. (8452887800)H. (8452887800)KaduszkiewiczWeyerer, S. (7006788675)S. (7006788675)WeyererBickel, H. (7006060834)H. (7006060834)BickelRiedel-Heller, S. (35450387800)S. (35450387800)Riedel-HellerPentzek, M. (8724244500)M. (8724244500)PentzekWiese, B. (7006993208)B. (7006993208)WieseDichgans, M. (7004050470)M. (7004050470)DichgansWagner, M. (59762394500)M. (59762394500)WagnerJessen, F. (7006672877)F. (7006672877)JessenMaier, W. (36046783700)W. (36046783700)MaierDe Quervain, D.J.-F. (6603596748)D.J.-F. (6603596748)De Quervain2025-07-022025-07-022011https://doi.org/10.1038/mp.2009.133https://www.scopus.com/inward/record.uri?eid=2-s2.0-79151482325&doi=10.1038%2fmp.2009.133&partnerID=40&md5=250e50af6bbfca108fecba4f09a9e8cchttps://remedy.med.bg.ac.rs/handle/123456789/14067Recent advances in the development of high-throughput genotyping platforms allow for the unbiased identification of genes and genomic sequences related to heritable traits. In this study, we analyzed human short-term memory, which refers to the ability to remember information over a brief period of time and which has been found disturbed in many neuropsychiatric conditions, including schizophrenia and depression. We performed a genome-wide survey at 909 622 polymorphic loci and report six genetic variations significantly associated with human short-term memory performance after genome-wide correction for multiple comparisons. A polymorphism within SCN1A (encoding the α subunit of the type I voltage-gated sodium channel) was replicated in three independent populations of 1699 individuals. Functional magnetic resonance imaging during an n-back working memory task detected SCN1A allele-dependent activation differences in brain regions typically involved in working memory processes. These results suggest an important role for SCN1A in human short-term memory. © 2011 Macmillan Publishers Limited All rights reserved.fMRIfunctional brain imagingGWASmemorySCN1Asodium channel