Nenezić, Dragoslav (9232882900)Dragoslav (9232882900)NenezićRadak, Djordje (7004442548)Djordje (7004442548)RadakJocić, Dario (25121522300)Dario (25121522300)JocićGajin, Predrag (15055548600)Predrag (15055548600)GajinTanasković, Slobodan (25121572000)Slobodan (25121572000)TanaskovićNovaković, Aleksandra (6602915174)Aleksandra (6602915174)NovakovićMatić, Predrag (25121600300)Predrag (25121600300)Matić2025-06-122025-06-122014https://doi.org/10.2298/SARH1406342Nhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84924247683&doi=10.2298%2fSARH1406342N&partnerID=40&md5=ba41b334d1a8902cc1c06a166523929fhttps://remedy.med.bg.ac.rs/handle/123456789/8751Introduction Acute lower limb ischemia results from thrombosis or embolization of diseased native artery or previously implanted bypass graft. When this occurs, several options are available to restore blood flow: catheter-directed thrombolysis, mechanical thrombectomy or open surgery. Fundamental reasons to apply percutaneous interventions are avoiding open procedures in high risk patients, and avoiding difficult dissection through scar tissue. Case Outline A 67-year-old male was admitted at our Institution for critical limb ischemia. After performed angiography the diagnosis of occluded femoropopliteal graft was established. Occlusion was resolved by catheter-directed thrombolysis with plasmin. Culprit lesions were treated by angioplasty. Conclusion Our patient underwent a successful thrombolysis of occluded femoropopliteal graft with locally-delivered human plasmin. © 2014, Serbia Medical Society. All rights reserved.Catheter-directed thrombolysisFemoropopliteal bypassHuman plasminPercutaneous intervention