Perić, Aleksandar (36763628500)Aleksandar (36763628500)PerićKovačević, Sandra Vezmar (57204567668)Sandra Vezmar (57204567668)KovačevićBarać, Aleksandra (55550748700)Aleksandra (55550748700)BaraćGaćeša, Dejan (25421621400)Dejan (25421621400)GaćešaPerić, Aneta V. (24825091000)Aneta V. (24825091000)PerićJožin, Svjetlana Matković (57208573803)Svjetlana Matković (57208573803)Jožin2025-06-122025-06-122019https://doi.org/10.1080/00016489.2019.1605454https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065207973&doi=10.1080%2f00016489.2019.1605454&partnerID=40&md5=8bac422763d740d9fdb396a7254e205ehttps://remedy.med.bg.ac.rs/handle/123456789/5551Background: Aspirin-induced chronic rhinosinusitis (CRS) is a severe progressive persistent disease, usually associated with nasal polyps (NPs). Aim/objective: To compare effect of hypertonic (2.3% NaCl) sea water and isotonic 0.9% NaCl on symptoms and endoscopic findings in those patients in the period of 1 month after endoscopic sinus surgery (ESS). Material and methods: This prospective, randomized study included 30 patients with aspirin-induced CRS undergoing ESS. Patients were divided into two groups of 15 subjects and one of the two nasal irrigation solutions was administered in each group. Intensity of 5 symptoms (nasal obstruction, nasal discharge/postnasal drip, facial pain/pressure, headache and trouble sleeping) and endoscopic findings were assessed during the 1st, 7th, 14th, 21st and 28th days after the nasal packs removal. Results: We found significantly lower total symptom score (TSS) during the 7th (p =.009), 14th (p =.003), 21st (p <.001) and the 28th day (p =.001), lower total endoscopic score (TES) on the 21st (p =.002) and 28th day (p =.001), lower nasal obstruction, facial pain/pressure, headache and trouble sleeping, and lower nasal mucosal edema, nasal secretion and nasal crusting in patients treated by hypertonic sea water. Conclusion and significance: Hypertonic sea water should be recommended douching solution in the early postoperative care of patients with aspirin-induced CRS. © 2019, © 2019 Acta Oto-Laryngologica AB (Ltd).Aspirinnasal polypsnasal surgical procedurespostoperative caresinusitis