Papassotiropoulos, A. (57207584929)A. (57207584929)PapassotiropoulosStefanova, E. (7004567022)E. (7004567022)StefanovaVogler, C. (24074940400)C. (24074940400)VoglerGschwind, L. (24381604600)L. (24381604600)GschwindAckermann, S. (54395088000)S. (54395088000)AckermannSpalek, K. (54785281400)K. (54785281400)SpalekRasch, B. (13607629500)B. (13607629500)RaschHeck, A. (24605001700)A. (24605001700)HeckAerni, A. (6507564517)A. (6507564517)AerniHanser, E. (54395492000)E. (54395492000)HanserDemougin, P. (55925139100)P. (55925139100)DemouginHuynh, K.-D. (8574293800)K.-D. (8574293800)HuynhLuechinger, R. (6506832948)R. (6506832948)LuechingerKlarhöfer, M. (6506839497)M. (6506839497)KlarhöferNovakovic, I. (6603235567)I. (6603235567)NovakovicKostic, V. (57189017751)V. (57189017751)KosticBoesiger, P. (7004947285)P. (7004947285)BoesigerScheffler, K. (24612381900)K. (24612381900)SchefflerDe Quervain, D.J.-F. (6603596748)D.J.-F. (6603596748)De Quervain2025-07-022025-07-022013https://doi.org/10.1038/mp.2011.148https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873060948&doi=10.1038%2fmp.2011.148&partnerID=40&md5=55ccc6edf59fe99759022851445666a5https://remedy.med.bg.ac.rs/handle/123456789/13959Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10 -8) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory. © 2013 Macmillan Publishers Limited.beta-catenin-likefMRIGWASmemory