Nikolić, Nataša (58288723700)Nataša (58288723700)NikolićPoluga, Jasmina (6507116358)Jasmina (6507116358)PolugaMilošević, Ivana (58456808200)Ivana (58456808200)MiloševićTodorović, Nevena (58688792000)Nevena (58688792000)TodorovićFilipović, Ana (58487006900)Ana (58487006900)FilipovićJegorović, Boris (55427940600)Boris (55427940600)JegorovićMitrović, Nikola (55110096400)Nikola (55110096400)MitrovićKarić, Uroš (57201195591)Uroš (57201195591)KarićGmizić, Ivana (57205466405)Ivana (57205466405)GmizićStevanović, Goran (15059280200)Goran (15059280200)StevanovićMilošević, Branko (57204639427)Branko (57204639427)Milošević2025-06-122025-06-122024https://doi.org/10.1007/s10072-023-07025-yhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85168601057&doi=10.1007%2fs10072-023-07025-y&partnerID=40&md5=c2fd1eaa0cb9167c9d8f60ac7282b84chttps://remedy.med.bg.ac.rs/handle/123456789/1263Introduction: We aimed to describe neurological manifestations and functional outcome at discharge in patients with West Nile neuroinvasive disease. Methods: This retrospective study enrolled inpatients treated in the University Clinic for Infectious and Tropical Diseases in Belgrade, Serbia, from 1 June until 31 October 2022. Functional outcome at discharge was assessed using modified Rankin scale. Results: Among the 135 analyzed patients, encephalitis, meningitis and acute flaccid paralysis (AFP) were present in 114 (84.6%), 20 (14.8%), and 21 (15.6%), respectively. Quadriparesis/quadriplegia and monoparesis were the most frequent forms of AFP, present in 9 (6.7%) and 6 (4.4%) patients, respectively. Fourty-five (33.3%) patients had cerebellitis, 80 (59.3%) had rhombencephalitis, and 5 (3.7%) exhibited Parkinsonism. Ataxia and wide-based gait were present in 79 (58.5%) patients each. Fifty-one (37.8%) patients had tremor (41 (30.3%) had postural and/or kinetic tremor, 10 (7.4%) had resting tremor). Glasgow coma score (GCS) ≤ 8 and respiratory failure requiring mechanical ventilation developed in 39 (28.9%), and 33 (24.4%) patients, respectively. Quadriparesis was a risk factor for prolonged ventilator support (29.5 ± 16.8 vs. 12.4 ± 8.7 days, p = 0.001). At discharge, one patient with monoparesis recovered full muscle strength, whereas 8 patients with AFP were functionally dependent. Twenty-nine (21.5%) patients died. All of the succumbed had encephalitis, and 7 had quadriparesis. Ataxia, tremor and cognitive deficit persisted in 18 (16.9%), 15 (14.2%), and 22 (16.3%) patients at discharge, respectively. Age, malignancy, coronary disease, quadriparesis, mechanical ventilation, GCS ≤ 8 and healthcare-associated infections were risk factors for death (p = 0.001; p = 0.019; p = 0.004; p = 0.001; p < 0.001; p < 0.001, and p < 0.001, respectively). © 2023, Fondazione Società Italiana di Neurologia.Movement DisordersNeuroinvasive diseaseOutcomeWest Nile virus