Radojevic, Nemanja (53871771600)Nemanja (53871771600)RadojevicRadnic, Bojana (55245986600)Bojana (55245986600)RadnicVucinic, Jelena (57191898956)Jelena (57191898956)VucinicCukic, Dragana (53871125500)Dragana (53871125500)CukicLazovic, Ranko (12761339100)Ranko (12761339100)LazovicAsanin, Bogdan (25923302700)Bogdan (25923302700)AsaninSavic, Slobodan (7005859439)Slobodan (7005859439)Savic2025-06-122025-06-122017https://doi.org/10.1016/j.jflm.2016.11.006https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000500977&doi=10.1016%2fj.jflm.2016.11.006&partnerID=40&md5=bf632fde4c9745730955f07984583997https://remedy.med.bg.ac.rs/handle/123456789/7366Current autopsy principles for evaluating the existence of brain edema are based on a macroscopic subjective assessment performed by pathologists. The gold standard is a time-consuming histological verification of the presence of the edema. By measuring the diameters of the cranial cavity, as individually determined morphometric parameters, a mathematical model for rapid evaluation of brain edema was created, based on the brain weight measured during the autopsy. A cohort study was performed on 110 subjects, divided into two groups according to the histological presence or absence of (the – deleted from the text) brain edema. In all subjects, the following measures were determined: the volume and the diameters of the cranial cavity (longitudinal and transverse distance and height), the brain volume, and the brain weight. The complex mathematical algorithm revealed a formula for the coefficient ε, which is useful to conclude whether a brain edema is present or not. The average density of non-edematous brain is 0.967 g/ml, while the average density of edematous brain is 1.148 g/ml. The resulting formula for the coefficient ε is (5.79 x longitudinal distance x transverse distance)/brain weight. Coefficient ε can be calculated using measurements of the diameters of the cranial cavity and the brain weight, performed during the autopsy. If the resulting ε is less than 0.9484, it could be stated that there is cerebral edema with a reliability of 98.5%. The method discussed in this paper aims to eliminate the burden of relying on subjective assessments when determining the presence of a brain edema. © 2016 Elsevier Ltd and Faculty of Forensic and Legal MedicineAutopsyBrain edemaBrain swellingCranial cavity