Radovanovic, Slavica (24492602300)Slavica (24492602300)RadovanovicKrotin, Mirjana (25632332600)Mirjana (25632332600)KrotinSimic, Dragan V. (57212512386)Dragan V. (57212512386)SimicMimic-Oka, Jasmina (56022732500)Jasmina (56022732500)Mimic-OkaSavic-Radojevic, Ana (16246037100)Ana (16246037100)Savic-RadojevicPljesa-Ercegovac, Marija (16644038900)Marija (16644038900)Pljesa-ErcegovacMatic, Marija (58618962300)Marija (58618962300)MaticNinkovic, Nebojsa (24492203800)Nebojsa (24492203800)NinkovicIvanovic, Branislava (24169010000)Branislava (24169010000)IvanovicSimic, Tatjana (6602094386)Tatjana (6602094386)Simic2025-06-122025-06-122008https://doi.org/10.1179/135100008X259204https://www.scopus.com/inward/record.uri?eid=2-s2.0-48749103531&doi=10.1179%2f135100008X259204&partnerID=40&md5=e2ad334fbb2f2ed4faf47153c5dff323https://remedy.med.bg.ac.rs/handle/123456789/10709Background: We aimed to study the relationship between markers of oxidative lipid or protein damage and ventricular remodeling and the validity of 8-epi-prostaglandin F2α (8-epi-PGF2α) as an indicator of disease severity in patients with ischemic chronic heart failure (CHF). Patients and methods: We enrolled four groups of 12 patients with varying CHF according to the New York Heart Association (NYHA) classification and 25 controls. Urinary 8-epi-PGF2α and plasma malondialdehyde and protein thiol (P-SH) groups were correlated with echocardiographic indices of remodeling. The reliability of isoprostanes was analyzed by a receiver operating characteristics (ROC) curve. Results: NYHA class III and IV patients exhibited elevated 8-epi-PGF2α levels, increased malondialdehyde concentrations and decreased P-SH groups when compared to controls and NYHA I and II patients. 8-Epi-PGF2α and P-SH groups correlated significantly with indices of remodeling. The ROC curve drawn for 8-epi-PGF2α allowed us to differentiate NYHA class III and IV patients from NYHA class I and II patients with a sensitivity of 95.8% and specificity of 95.8% (cut off 0.84 ng/mg creatinine; area under curve 0.99; P < 0.001). Conclusions: Markers of oxidative damage are unlikely to play a significant role in early stages of CHF. However, they might become important in the course of CHF when their concentrations reach critical levels. Urinary 8-epi-PGF2α is a reliable indicator of symptomatic CHF. © 2008 W. S. Maney and Son Ltd.8-epi-PGF_2αChronic heart failureOxidative damage