Šipetić, Sandra B. (6701802171)Sandra B. (6701802171)ŠipetićVlajinac, Hristina D. (7006581450)Hristina D. (7006581450)VlajinacKocev, Nikola I. (6602672952)Nikola I. (6602672952)KocevMarinković, Jelena M. (7004611210)Jelena M. (7004611210)MarinkovićRadmanović, Slobodan Z. (6602183428)Slobodan Z. (6602183428)RadmanovićBjekić, Milan D. (6602745387)Milan D. (6602745387)Bjekić2025-06-132025-06-132005https://doi.org/10.1093/eurpub/cki074https://www.scopus.com/inward/record.uri?eid=2-s2.0-20644439095&doi=10.1093%2feurpub%2fcki074&partnerID=40&md5=eb58db8cad94100c03dd26e14717b118https://remedy.med.bg.ac.rs/handle/123456789/11088Background: The aim of this study was to evaluate some hypotheses about factors related to the development of type 1 diabetes mellitus. Methods: A case-control study was conducted in Belgrade during the period 1994-1997. A total of 105 recently onset diabetic and 210 control children, individually matched by age (± 1 year), sex and place of residence, were included in the study. Results: According to multivariate regression analysis, the following factors were related to type 1 diabetes: stressful events and symptoms of psychological dysfunction during the 12 months preceding the onset of the disease [odds ratio (OR) 3.48, 95% confidence interval (CI) 2.15-5.65; and OR 2.15, 95% CI 1.33-3.48], irregular vaccination (OR 16.98, 95% CI 1.38-208.92), infection during 6 months preceding the onset of the disease (OR 4.23, 95% CI 1.95-9.17), higher education of father (OR 1.50, 95% CI 1.05-2.14), mother's consumption of nitrosoamines-rich food during pregnancy (OR 4.33, 95% CI 1.95-9.61), alcohol consumption by father (OR 3.80, 95% CI 1.64-8.78), insulin-dependent and non-insulin-dependent diabetes mellitus in three generations of children's relatives (OR 20.04, 95% CI 4.73-84.81; and OR 5.52, 95% CI 2.45-12.46), and use of ultrasound diagnostic techniques during pregnancy (OR 0.42, 95% CI 0.17-1.00). Conclusions: Among non-genetic factors, those affecting the child during pregnancy are especially important because of their preventability. © The Author 2005. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.Case-control studyEpidemiologyRisk factorsType 1 diabetes mellitus