Du, Qingyou (14035606200)Qingyou (14035606200)DuJovanović, Sofija (57194064227)Sofija (57194064227)JovanovićTulić, Lidija (6504063680)Lidija (6504063680)TulićTulić, Ivan (6602743219)Ivan (6602743219)TulićJovanović, Aleksandar (7006571994)Aleksandar (7006571994)Jovanović2025-06-122025-06-122019https://doi.org/10.1016/j.preghy.2019.09.008https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072729690&doi=10.1016%2fj.preghy.2019.09.008&partnerID=40&md5=c779b8a0512ada1f151310dc46c80e68https://remedy.med.bg.ac.rs/handle/123456789/5373It is generally accepted that activity of K+ channels maintain resting membrane potential and uterine quiescence during pregnancy, which is, at least in part, mediated by down-regulation of ATP-sensitive K+ (KATP) channels. Pregnancy-induced hypertension (PIH) is associated with pre-term and late pre-term labour. Here, we have used real time RT-PCR to compare mRNA levels of KATP channel subunits in PIH parturient and control parturient. We have found that Kir6.1, a pore forming, myometrial KATP channel subunit is down-regulated in PIH patients. This could perfectly explain increased rate of pre-term labour in patients suffering from PIH. © 2019 International Society for the Study of Hypertension in PregnancyATP-sensitive K⁺ channelsPIHUterus