Životić, Maja (56320853500)Maja (56320853500)ŽivotićBogdanović, Radovan (7004665744)Radovan (7004665744)BogdanovićPeco-Antić, Amira (7004525216)Amira (7004525216)Peco-AntićParipović, Dušan (14621764400)Dušan (14621764400)ParipovićStajić, Nataša (6602606131)Nataša (6602606131)StajićVještica, Jelena (55221842700)Jelena (55221842700)VješticaĆirović, Sanja (36027425000)Sanja (36027425000)ĆirovićTrajković, Goran (9739203200)Goran (9739203200)TrajkovićMarković-Lipkovski, Jasmina (6603725388)Jasmina (6603725388)Marković-Lipkovski2025-06-122025-06-122015https://doi.org/10.1007/s00467-014-2893-5https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937512228&doi=10.1007%2fs00467-014-2893-5&partnerID=40&md5=1de6e8c30ed731ebe38aca7bfb73f301https://remedy.med.bg.ac.rs/handle/123456789/8438Conclusions: The most important finding of our study is that nestin can be used as a potential new early morphological predictor of kidney dysfunction in childhood onset of FSGS, since nestin has been obviously decreased in both sclerotic and normal glomeruli seen by light microscopy.; Methods: Among 649 renal biopsy samples, obtained from two children’s hospitals, FSGS was diagnosed in 60 children. Thirty-eight patients, who met the criteria for this study, were followed up for 9.0 ± 5.2 years. Using Kaplan–Meier and Cox’s regression analysis, potential clinical and morphological predictors were applied in two models of prediction: after disease onset and after the biopsy.; Results: The present study revealed the following significant predictors of kidney dysfunction: patients’ ages at disease onset, as well as age at biopsy, resistance to corticosteroid treatment, serum creatinine level, urine protein/creatinine ratio, vascular involvement, tubular atrophy, interstitial fibrosis, and decreased glomerular nestin expression.; Background: A high prevalence of chronic kidney disease among children with focal segmental glomerulosclerosis (FSGS) leads to a permanent quest for good predictors of kidney dysfunction. Thus, we carried out a retrospective cohort study in order to examine known clinical and morphological predictors of adverse outcome, as well as to investigate glomerular nestin expression as a potential new early predictor of kidney dysfunction in children with FSGS. Relationships between nestin expression and clinical and morphological findings were also investigated. © 2014, IPNA.CKDFSGSNestinPodocyteProteinuriaSRNSSurvival analysis