Djurić-Jovičić, Milica (26633912900)Milica (26633912900)Djurić-JovičićPetrović, Igor (7004083314)Igor (7004083314)PetrovićJečmenica-Lukić, Milica (35801126700)Milica (35801126700)Ječmenica-LukićRadovanović, Saša (6604015284)Saša (6604015284)RadovanovićDragašević-Mišković, Nataša (59157743200)Nataša (59157743200)Dragašević-MiškovićBelić, Minja (57189989195)Minja (57189989195)BelićMiler-Jerković, Vera (55027360300)Vera (55027360300)Miler-JerkovićPopović, Mirjana B. (55300928500)Mirjana B. (55300928500)PopovićKostić, Vladimir S. (57189017751)Vladimir S. (57189017751)Kostić2025-07-022025-07-022016https://doi.org/10.1016/j.jocn.2015.10.053https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976333829&doi=10.1016%2fj.jocn.2015.10.053&partnerID=40&md5=139908039dc29f20189d55f705c822b6https://remedy.med.bg.ac.rs/handle/123456789/13344The goal of this study was to investigate repetitive finger tapping patterns in patients with Parkinson's disease (PD), progressive supranuclear palsy-Richardson syndrome (PSP-R), or multiple system atrophy of parkinsonian type (MSA-P). The finger tapping performance was objectively assessed in PD (n = 13), PSP-R (n = 15), and MSA-P (n = 14) patients and matched healthy controls (HC; n = 14), using miniature inertial sensors positioned on the thumb and index finger, providing spatio-temporal kinematic parameters. The main finding was the lack or only minimal progressive reduction in amplitude during the finger tapping in PSP-R patients, similar to HC, but significantly different from the sequence effect (progressive decrement) in both PD and MSA-P patients. The mean negative amplitude slope of -0.12°/cycle revealed less progression of amplitude decrement even in comparison to HC (-0.21°/cycle, p = 0.032), and particularly from PD (-0.56°/cycle, p = 0.001), and MSA-P patients (-1.48°/cycle, p = 0.003). No significant differences were found in the average finger separation amplitudes between PD, PSP-R and MSA-P patients (pmsa-pd = 0.726, pmsa-psp = 0.363, ppsp-pd = 0.726). The lack of clinically significant sequence effect during finger tapping differentiated PSP-R from both PD and MSA-P patients, and might be specific for PSP-R. The finger tapping kinematic parameter of amplitude slope may be a neurophysiological marker able to differentiate particular forms of parkinsonism. © 2016 Elsevier Ltd. All rights reserved.Atypical parkinsonismHypokinesiaKinematic analysisProgressive supranuclear palsyRepetitive finger tapping