Filipovic, Branislav R. (56207614900)Branislav R. (56207614900)FilipovicJovic, Nebojsa J. (56367047200)Nebojsa J. (56367047200)JovicFilipovic, Branka F. (22934489100)Branka F. (22934489100)FilipovicIlankovic, Andrej N. (6504509995)Andrej N. (6504509995)IlankovicIlankovic, Nikola N. (6602237318)Nikola N. (6602237318)Ilankovic2025-06-132025-06-132006https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846661660&partnerID=40&md5=d752af63f009fc809d6dedb16c1aa3ebhttps://remedy.med.bg.ac.rs/handle/123456789/10941Small cava septi pellucidi (CSP) are sometimes automatically regarded as an anatomical variation (asymptomatic CSP), especially if they could not be associated with a neuropsychiatric disorder, like schizophrenia or alcoholism (symptomatic CSP). Our aim was to investigate the impact of symptomatic CSP in the population in which CSP length was less or equal to 6 mm (criterion established by Nopoulos et al in 1997). We have overlooked 479 post mortem brains that underwent serial frozen sections in the axial plane on 1.5 mm of thickness. A sample of 110 CSP was obtained, among which 50 were adequate for this study. In our sample, 26 CSP were asymptomatic, 13 were on alcoholic brains, 6 were obtained from subjects who faced one or several head trauma and later manifested aggressive behavior, and remaining 5 belonged to schizophrenics. There were no major differences in lengths and widths measured, except between the lengths of CSP in schizophrenics and alcoholics (p<0.05, Bonferroni post hoc correction). Cava shorter or equal to 6 mm were normal variation in more than a half of our sample. Symptomatic CSP had a representative impact of 48%, out of which majority was revealed in alcoholics. We suggest a precaution before classify a small CSP into anatomical variations.AlcoholismCavumHead traumaSchizophreniaSeptum pellacidum