Mazibrada, Ilijana (12239600600)Ilijana (12239600600)MazibradaDjukić, Tatjana (36193753800)Tatjana (36193753800)DjukićPerović, Svetlana (57193408904)Svetlana (57193408904)PerovićPlješa-Ercegovac, Marija (16644038900)Marija (16644038900)Plješa-ErcegovacPlavšić, Ljiljana (6505599081)Ljiljana (6505599081)PlavšićBojanin, Dragana (56060584100)Dragana (56060584100)BojaninBjekić-Macut, Jelica (54400683700)Jelica (54400683700)Bjekić-MacutSimić, Petar D. (57204457102)Petar D. (57204457102)SimićSimić, Tatjana (6602094386)Tatjana (6602094386)SimićSavić-Radojević, Ana (16246037100)Ana (16246037100)Savić-RadojevićMastorakos, George (18335926100)George (18335926100)MastorakosMacut, Djuro (35557111400)Djuro (35557111400)Macut2025-06-122025-06-122018https://doi.org/10.1515/jpem-2017-0511https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055647394&doi=10.1515%2fjpem-2017-0511&partnerID=40&md5=cdafb1158bb8eb281cb10aa701cb017chttps://remedy.med.bg.ac.rs/handle/123456789/6094The aim of the study was to evaluate high-sensitivity C-reactive protein (hs-CRP) and fibrinogen in non-obese normoinsulinemic adolescent girls with polycystic ovary syndrome (PCOS) and their relationship with anthropometric and lipid parameters. The study comprised a total of 26 adolescent girls newly diagnosed with PCOS and 12 healthy controls with regular ovulatory menstrual cycles. The concentration of hs-CRP, fibrinogen, anthropometric measurements, and biochemical and hormonal testing were assessed. PCOS adolescent girls had significantly higher levels of hs-CRP and fibrinogen compared to healthy controls. In univariate regression analysis, statistically significant associations of hs-CRP and fibrinogen levels of PCOS patients have been shown with body mass index (BMI), waist circumference (WC), hip circumference (HC) and low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio, while hs-CRP levels were also associated with cholesterol and LDL. In the multivariate regression model, we found that hs-CRP levels were predicted by BMI (β=0.541, p<0.001) and LDL (β=0.507, p=0.014), while fibrinogen levels were predicted by BMI (β=0.449, p=0.004). We have shown an association of proinflammatory indices hs-CRP and fibrinogen with anthropometric and lipid parameters of adolescent women with PCOS. The inflammatory markers might be useful in monitoring normal-weight adolescent women with PCOS in an effort to timely prevent unfavorable changes in body mass and lipid profile. © 2018 2018 Walter de Gruyter GmbH, Berlin/Boston.C-reactive proteincardiovascular riskfibrinogeninflammationpolycystic ovary syndrome