Ivković, Maja (6603636580)Maja (6603636580)IvkovićPantović-Stefanović, Maja (35085268700)Maja (35085268700)Pantović-StefanovićPetronijević, Nataša (6506911099)Nataša (6506911099)PetronijevićDunjić-Kostić, Bojana (36760738400)Bojana (36760738400)Dunjić-KostićVelimirović, Milica (56270007000)Milica (56270007000)VelimirovićNikolić, Tatjana (57235024600)Tatjana (57235024600)NikolićJurišić, Vladimir (6603015144)Vladimir (6603015144)JurišićLačković, Maja (23004732800)Maja (23004732800)LačkovićTotić-Poznanović, Sanja (9241787500)Sanja (9241787500)Totić-PoznanovićJovanović, Aleksandar A. (58423375000)Aleksandar A. (58423375000)JovanovićDamjanović, Aleksandar (7004519596)Aleksandar (7004519596)Damjanović2025-06-122025-06-122017https://doi.org/10.1016/j.jad.2016.09.017https://www.scopus.com/inward/record.uri?eid=2-s2.0-84989184504&doi=10.1016%2fj.jad.2016.09.017&partnerID=40&md5=f4118f8f7365328b65ce0e4d6da7895ehttps://remedy.med.bg.ac.rs/handle/123456789/7411Background Affective temperaments are intermediate phenotypes for major affective disorders and are reported to have a neuroimmune etiopathogenesis. Here we investigated the role of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in affective temperaments and mood symptoms in healthy adults. Methods Healthy adults (n=94) were screened for psychiatric disorders using the nonpatient version of the Structured Clinical Interview for DSM-IV-I and II. Subjects with medical conditions associated with changes in inflammatory response were excluded, deriving the final sample (n=68). Affective temperaments were evaluated with Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire (TEMPS-A). State mood symptoms were assessed using the Young Mania Rating Scale and Montgomery–Åsberg Depression Rating Scale. Serum sICAM-1 and sVCAM-1 levels were measured using enzyme-linked immunosorbent assay. Results After adjusting for confounders (age, gender, BMI, and smoking habits), a high negative correlation between depressive and irritable temperament TEMPS-A scores and sVCAM-1 levels was detected. Although we identified no association between sICAM-1 levels and affective temperament scores, sICAM-1 was related to the state severity of manic symptoms. In a multiple linear regression model, sVCAM-1 remained a significant predictor of depressive but not irritable temperament scores. Limitations The temperaments were estimated on the basis of self-report questionnaire. Conclusions Our findings suggest that sVCAM-1 is related to affective temperaments, and it is a trait marker for liability to mood disorders. This relationship between alterations in cellular adhesion and affective temperament may be important for vulnerability to affective disorders. © 2016 Elsevier B.V.Affective temperamentsCellular adhesionMood disordersPersonalitysICAM-1sVCAM-1