Hereditary thrombophilia and low-molecular-weight heparin in women: Useful determinants, including thyroid dysfunction, incorporating the management of treatment and outcomes of the entity

Dugalic, Stefan (26648755300)Stefan (26648755300)DugalicPetronijevic, Milica (58134579600)Milica (58134579600)PetronijevicSengul, Demet (22938589200)Demet (22938589200)SengulDetanac, Dzenana A. (36815573500)Dzenana A. (36815573500)DetanacSengul, Ilker (26323870100)Ilker (26323870100)SengulDe Arruda Veiga, Eduardo Carvalho (44462234600)Eduardo Carvalho (44462234600)De Arruda VeigaStanisavljevic, Tamara (57252613700)Tamara (57252613700)StanisavljevicMacura, Maja (57219966636)Maja (57219966636)MacuraTodorovic, Jovana (7003376825)Jovana (7003376825)TodorovicGojnic, Miroslava (9434266300)Miroslava (9434266300)Gojnic2025-06-122025-06-122023https://doi.org/10.1590/1806-9282.20221445https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149698973&doi=10.1590%2f1806-9282.20221445&partnerID=40&md5=48dde504991149424844bdaa96c62369https://remedy.med.bg.ac.rs/handle/123456789/3061OBJECTIVE: Our study purposed to examine the complex relationship between low-molecular-weight heparin therapy, multiple pregnancy determinants, and adverse pregnancy outcomes during the third trimester in women with inherited thrombophilia. METHODS: Patients were selected from a prospective cohort of 358 pregnant patients recruited between 2016 and 2018 at the Clinic for Obstetrics and Gynecology, University Clinical Centre of Serbia, Belgrade. RESULTS: Gestational age at delivery (β=-0.081, p=0.014), resistance index of the umbilical artery (β=0.601, p=0.039), and d-dimer (β=0.245, p<0.001) between 36th and 38th weeks of gestation presented the direct predictors for adverse pregnancy outcomes. The model fit was examined using the root mean square error of approximation 0.00 (95%CI 0.00 0.18), the goodness-of-fit index was 0.998, and the adjusted goodness-of-fit index was 0.966. CONCLUSION: There is a need for the introduction of more precise protocols for the assessment of hereditary thrombophilias and the need for the introduction of low-molecular-weight heparin. © 2023 Associacao Medica Brasileira. All rights reserved.Heparinhereditarylow-molecular-weight.PregnancyThrombophiliaThyroid glandHereditary thrombophilia and low-molecular-weight heparin in women: Useful determinants, including thyroid dysfunction, incorporating the management of treatment and outcomes of the entity