Longoni, Giulia (37070849300)Giulia (37070849300)LongoniAgosta, Federica (6701687853)Federica (6701687853)AgostaKostić, Vladimir S. (35239923400)Vladimir S. (35239923400)KostićStojković, Tanja (57211211787)Tanja (57211211787)StojkovićPagani, Elisabetta (7005421345)Elisabetta (7005421345)PaganiStošić-Opinćal, Tatjana (55886486600)Tatjana (55886486600)Stošić-OpinćalFilippi, Massimo (7202268530)Massimo (7202268530)Filippi2025-06-122025-06-122011https://doi.org/10.1002/mds.23293https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952663222&doi=10.1002%2fmds.23293&partnerID=40&md5=173b884206e0d899bec4fb8fe3ab3edahttps://remedy.med.bg.ac.rs/handle/123456789/10079We investigated the diagnostic accuracy of brainstem MRI measurements in patients with different progressive supranuclear palsy (PSP) syndromes and Parkinson's disease (PD). Using 3D T1-weighted images, midbrain, and pons areas, as well as superior (SCP) and middle cerebellar peduncle (MCP) widths were measured in 10 patients with Richardson's syndrome (PSP-RS), 10 patients with PSP-parkinsonism (PSP-P), 25 patients with PD, and 24 healthy controls. The ratio between pons and midbrain areas (pons/midbrain), that between MCP and SCP widths (MCP/SCP), and the MR parkinsonism index ([pons/midbrain]*[MCP/SCP]) were calculated. The pons/midbrain and the MR parkinsonism index allowed to differentiate PSP-RS from PD with high sensitivity (90%, 100%), specificity (96%, 92%), and accuracy (94%, 97%). Only the pons/midbrain was found to distinguish PSP-P from PD, but with a lower diagnostic accuracy (sensitivity = 60%, specificity = 96%, accuracy = 86%). Compared to PSP-RS, PSP-P experience a relatively less severe involvement of infratentorial brain. The pons/midbrain looks as a promising measure in the differentiation of individual PSP-P from PD patients. © 2010 Movement Disorder Society.AtrophyBrainstemMidbrainParkinson's diseaseProgressive supranuclear palsy