Ljubisavljevic, Srdjan (37665560500)Srdjan (37665560500)LjubisavljevicZidverc Trajkovic, Jasna (18134546100)Jasna (18134546100)Zidverc Trajkovic2025-07-022025-07-022020https://doi.org/10.1016/j.jocn.2020.03.043https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082437520&doi=10.1016%2fj.jocn.2020.03.043&partnerID=40&md5=a95730f899935bbb6778e26f0f2a8745https://remedy.med.bg.ac.rs/handle/123456789/12481The incidence of postdural puncture headache (PDPH) in relation to pre-existing chronic headache (CH) was assessed, as was the clinical course of CH, at one, three, and six months after PDPH. The study was conducted as a single center cohort prospective study that included 252 patients (105 men and 147 women), average age of 47.3 ± 15.0 years, on whom lumbar puncture (LP) was performed. PDPH was reported in 133 (52.8%) patients; CH was reported in 82 (32.5%) patients. Patients with CH were more likely to have PDPH (p = 0.003). The individual clinical type of CH did not have an effect on the incidence of PDPH (p = 0.128). Patients with PDPH had a clinical deterioration of CH three and six months after LP (p = 0.047, p = 0.027, respectively) in terms of increased headache days per month and/or incomplete efficacy of performed therapy in relation to baseline values. Six months after LP, the worsening of CH was more common in women with PDPH (OR 5,687 [95% CI: 1526–21,200], p = 0.010) and patients with a longer history of CH (OR 1064 [95% CI: 1007–1124], p = 0.027). Multivariate analysis confirmed the direct association of female sex and duration of CH and its worsening six months after PDPH (OR 4478 [95% CI: 1149–17,452], p = 0.031; OR 1448 [95% CI: 1292–1808], p = 0.022). The presented results could be significant for the prediction/differential diagnosis of PDPH in patients with CH and for the prediction/prevention of CH clinical worsening after PDPH. © 2020 Elsevier LtdLumbar puncturePostdural puncture headache