Kaitovic, Marko (37048782600)Marko (37048782600)KaitovicMicovic, Slobodan (25929461500)Slobodan (25929461500)MicovicNesic, Ivan (57219202239)Ivan (57219202239)NesicRaickovic, Tatjana (57217308817)Tatjana (57217308817)RaickovicDotlic, Jelena (6504769174)Jelena (6504769174)DotlicStojanovic, Ivan (55014093700)Ivan (55014093700)StojanovicGazibara, Tatjana (36494484100)Tatjana (36494484100)Gazibara2025-06-122025-06-122023https://doi.org/10.3390/medicina59061032https://www.scopus.com/inward/record.uri?eid=2-s2.0-85163706925&doi=10.3390%2fmedicina59061032&partnerID=40&md5=09564815ffcf2f2bef984a14d815ab7ahttps://remedy.med.bg.ac.rs/handle/123456789/2683Background and Objectives: There is a lack of data about the survival of patients after the implantation of sutureless relative to stented bioprostheses in middle-income settings. The objective of this study was to compare the survival of people with isolated severe aortic stenosis after the implantation of sutureless and stented bioprostheses in a tertiary referral center in Serbia. Materials and Methods: This retrospective cohort study included all people treated for isolated severe aortic stenosis with sutureless and stented bioprostheses from 1 January 2018 to 1 July 2021 at the Institute for Cardiovascular Diseases “Dedinje”. Demographic, clinical, perioperative and postoperative data were extracted from the medical records. The follow-up lasted for a median of 2 years. Results: The study sample comprised a total of 238 people with a stented (conventional) bioprosthesis and 101 people with a sutureless bioprosthesis (Perceval). Over the follow-up, 13.9% of people who received the conventional and 10.9% of people who received the Perceval valve died (p = 0.400). No difference in the overall survival was observed (p = 0.797). The multivariate Cox proportional hazard model suggested that being older, having a higher preoperative EuroScore II, having a stroke over the follow-up period and having valve-related complications were independently associated with all-cause mortality over a median of 2 years after the bioprosthesis implantation. Conclusions: This research conducted in a middle-income country supports previous findings in high-income countries regarding the survival of people with sutureless and stented valves. Survival after bioprosthesis implantation should be monitored long-term to ensure optimum postoperative outcomes. © 2023 by the authors.aortic valve replacementmiddle-income countryPerceval valvestented bioprosthesissurvivalsutureless bioprosthesis