Ćulafić, Dorde (6603664463)Dorde (6603664463)ĆulafićŠtulić, Miloš (55895099100)Miloš (55895099100)ŠtulićObrenović, Radmila (56199010700)Radmila (56199010700)ObrenovićMiletić, Danijela (7004219003)Danijela (7004219003)MiletićMijač, Dragana (16550439600)Dragana (16550439600)MijačStojković, Milica (37862065400)Milica (37862065400)StojkovićJovanović, Marija (55861891200)Marija (55861891200)JovanovićĆulafić, Milica (55881915300)Milica (55881915300)Ćulafić2025-06-122025-06-122014https://doi.org/10.3748/wjg.v20.i21.6573https://www.scopus.com/inward/record.uri?eid=2-s2.0-84902108875&doi=10.3748%2fwjg.v20.i21.6573&partnerID=40&md5=13940f1f4671b044d16090622356a26dhttps://remedy.med.bg.ac.rs/handle/123456789/8788AIM: To evaluate the clinical significance of cystatin C and renal resistive index for the determination of renal function in patients with liver cirrhosis. METHODS: We conducted a study of 63 patients with liver cirrhosis. A control group comprised of 30 age and gender-matched healthy persons. Serum cystatin C was determined in all study subjects and renal Doppler ultrasonography was made. Estimated glomerular filtration rate from serum creatinine (GFRCr) and cystatin C (GFRCys) was calculated. RESULTS: We confirmed significant differences in values of cystatin C between patients with different stages of liver cirrhosis according to Child-Pugh (P = 0.01), and a significant correlation with model of end stage liver disease (MELD) score (rs= 0.527, P < 0.001). More patients with decreased glomerular filtration rate were identified based on GFRCys than on GFRCr (P < 0.001). Significantly higher renal resistive index was noted in Child-Pugh C than in A (P < 0.001) and B stage (P = 0.001). Also, a significant correlation between renal resistive index and MELD score was observed (rs= 0.607, P < 0.001). Renal resistive index correlated significantly with cystatin C (rs= 0.283, P = 0.028) and showed a negative correlation with GFRCys (rs= -0.31, P = 0.016). CONCLUSION: Cystatin C may be a more reliable marker for assessment of liver insufficiency. Additionally, cystatin C and renal resistive index represent sensitive indicators of renal dysfunction in patients with liver cirrhosis. © 2014 Baishideng Publishing Group Inc. All rights reserved.Cystatin CLiver cirrhosisRenal resistive index