Jurisic, Vladimir (6603015144)Vladimir (6603015144)JurisicColovic, Natasa (6701607753)Natasa (6701607753)ColovicTerzic, Tatjana (55916182400)Tatjana (55916182400)TerzicDjordjevic, Vesna (57215460423)Vesna (57215460423)DjordjevicColovic, Milica (21639151700)Milica (21639151700)Colovic2025-06-122025-06-122012https://doi.org/10.1016/j.prp.2012.04.007https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863815856&doi=10.1016%2fj.prp.2012.04.007&partnerID=40&md5=7e970f53002ec896364782288a1d67a1https://remedy.med.bg.ac.rs/handle/123456789/9577A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia. Immunophenotyping of peripheral blood by flow cytometry showed HLA-DR, CD34, CD19, CD22, CD10, CD33, and CD11b positivity. Cytogenetic analysis revealed the presence of 20q- and Philadelphia chromosome t(9;22)(q34:q11) at the time of disease transformation to ALL. The JAK2V617F mutation was not found. This is a very rare case of simultaneous presence of two cytogenetics abnormalities and evolution of primary idiopathic myelofibrosis to Philadelphia-positive acute lymphoblastic leukemia. © 2012 Elsevier GmbH.20q-ALLCytogeneticsImmunophenotypeMutationMyelofibrosisPhiladelphia chromosomeTransformation