Visentin, Andrea (56989457100)Andrea (56989457100)VisentinChatzikonstantinou, Thomas (57217065912)Thomas (57217065912)ChatzikonstantinouScarfò, Lydia (28167825700)Lydia (28167825700)ScarfòKapetanakis, Anargyros (58623251000)Anargyros (58623251000)KapetanakisDemosthenous, Christos (56611867600)Christos (56611867600)DemosthenousKarakatsoulis, Georgios (57220596370)Georgios (57220596370)KarakatsoulisMinga, Eva (36241991000)Eva (36241991000)MingaChamou, Dimitra (57211408425)Dimitra (57211408425)ChamouAllsup, David (6602087464)David (6602087464)AllsupCabrero, Alejandro Alonso (57321136300)Alejandro Alonso (57321136300)CabreroAndres, Martin (23977521200)Martin (23977521200)AndresAntic, Darko (23979576100)Darko (23979576100)AnticBaile, Mónica (57195953490)Mónica (57195953490)BaileBaliakas, Panagiotis (54961768800)Panagiotis (54961768800)BaliakasBesikli-Dimou, Sotiria (58697452700)Sotiria (58697452700)Besikli-DimouBron, Dominique (7005738621)Dominique (7005738621)BronChatzileontiadou, Sofia (16743810600)Sofia (16743810600)ChatzileontiadouCordoba, Raul (46661792200)Raul (46661792200)CordobaCorrea, Juan-Gonzalo (56702012300)Juan-Gonzalo (56702012300)CorreaCuéllar-García, Carolina (57202921956)Carolina (57202921956)Cuéllar-GarcíaDe Paoli, Lorenzo (19933476900)Lorenzo (19933476900)De PaoliDe Paolis, Maria Rosaria (6701556193)Maria Rosaria (6701556193)De PaolisDelgado, Julio (57210543223)Julio (57210543223)DelgadoDimou, Maria (55640732800)Maria (55640732800)DimouDonaldson, David (57205680457)David (57205680457)DonaldsonCatherwood, Mark (56020956700)Mark (56020956700)CatherwoodDoubek, Michael (7003925108)Michael (7003925108)DoubekEfstathopoulou, Maria (57189039505)Maria (57189039505)EfstathopoulouEichhorst, Barbara (6602247517)Barbara (6602247517)EichhorstElashwah, Salma (57901750900)Salma (57901750900)ElashwahEnrico, Alicia (35733695900)Alicia (35733695900)EnricoEspinet, Blanca (7004259456)Blanca (7004259456)EspinetFarina, Lucia (14038893700)Lucia (14038893700)FarinaFerrari, Angela (57206392567)Angela (57206392567)FerrariFoglietta, Myriam (6507159951)Myriam (6507159951)FogliettaFrederiksen, Henrik (7005676625)Henrik (7005676625)FrederiksenFürstenau, Moritz (57209250588)Moritz (57209250588)FürstenauGarcía-Marco, José A. (6604055220)José A. (6604055220)García-MarcoGarcía-Serra, Rocío (57226301809)Rocío (57226301809)García-SerraCollado, Rosa (14324236800)Rosa (14324236800)ColladoGentile, Massimo (7101638338)Massimo (7101638338)GentileGimeno, Eva (7005822086)Eva (7005822086)GimenoGlenthøj, Andreas (16041864000)Andreas (16041864000)Glenthøjda Silva, Maria Gomes (15845705200)Maria Gomes (15845705200)da SilvaHakobyan, Yervand K. (57217859653)Yervand K. (57217859653)HakobyanHerishanu, Yair (7005969341)Yair (7005969341)HerishanuHernández-Rivas, José Ángel (56469275700)José Ángel (56469275700)Hernández-RivasHerold, Tobias (15727707300)Tobias (15727707300)HeroldInnocenti, Idanna (24398951900)Idanna (24398951900)InnocentiItchaki, Gilad (55986041000)Gilad (55986041000)ItchakiJaksic, Ozren (6602660310)Ozren (6602660310)JaksicJanssens, Ann (8925032200)Ann (8925032200)JanssensKalashnikova, Оlga B. (57320897600)Оlga B. (57320897600)KalashnikovaKalicińska, Elżbieta (8288488300)Elżbieta (8288488300)KalicińskaKater, Arnon P. (6603351373)Arnon P. (6603351373)KaterKersting, Sabina (23094498300)Sabina (23094498300)KerstingLabrador, Jorge (55180317500)Jorge (55180317500)LabradorLad, Deepesh (55371865400)Deepesh (55371865400)LadLaurenti, Luca (7007012358)Luca (7007012358)LaurentiLevin, Mark-David (51964222700)Mark-David (51964222700)LevinLista, Enrico (55836340900)Enrico (55836340900)ListaLopez-Garcia, Alberto (57302214600)Alberto (57302214600)Lopez-GarciaMalerba, Lara (6701456950)Lara (6701456950)MalerbaMarasca, Roberto (7004286886)Roberto (7004286886)MarascaMarchetti, Monia (8588578000)Monia (8588578000)MarchettiMarquet, Juan (57193615332)Juan (57193615332)MarquetMattsson, Mattias (57040836700)Mattias (57040836700)MattssonMauro, Francesca R. (7005890659)Francesca R. (7005890659)MauroMorawska, Marta (35082453800)Marta (35082453800)MorawskaMotta, Marina (57214566407)Marina (57214566407)MottaMunir, Talha (35105475800)Talha (35105475800)MunirMurru, Roberta (6603206833)Roberta (6603206833)MurruNiemann, Carsten U. (8927104700)Carsten U. (8927104700)NiemannRodrigues, Raquel Nunes (57321362500)Raquel Nunes (57321362500)RodriguesOlivieri, Jacopo (36717840500)Jacopo (36717840500)OlivieriOrsucci, Lorella (6602896495)Lorella (6602896495)OrsucciPapaioannou, Maria (57211363643)Maria (57211363643)PapaioannouPavlovsky, Miguel Arturo (36956468000)Miguel Arturo (36956468000)PavlovskyPiskunova, Inga (57197785044)Inga (57197785044)PiskunovaPopov, Viola Maria (55508298300)Viola Maria (55508298300)PopovQuaglia, Francesca Maria (57188538306)Francesca Maria (57188538306)QuagliaQuaresmini, Giulia (15837925000)Giulia (15837925000)QuaresminiQvist, Kristian (57219204982)Kristian (57219204982)QvistRigolin, Gian Matteo (35461048500)Gian Matteo (35461048500)RigolinRuchlemer, Rosa (35497424700)Rosa (35497424700)RuchlemerŠimkovič, Martin (55745666200)Martin (55745666200)ŠimkovičŠpaček, Martin (6602104203)Martin (6602104203)ŠpačekSportoletti, Paolo (15124502200)Paolo (15124502200)SportolettiStanca, Oana (55859519600)Oana (55859519600)StancaTadmor, Tamar (14072032100)Tamar (14072032100)TadmorCapasso, Antonella (57203978270)Antonella (57203978270)CapassoDel Poeta, Giovanni (7003523315)Giovanni (7003523315)Del PoetaGutwein, Odit (53263895500)Odit (53263895500)GutweinKarlsson, Linda Katharina (57303008700)Linda Katharina (57303008700)KarlssonMilosevic, Ivana (24767978000)Ivana (24767978000)MilosevicMirás, Fatima (57210113536)Fatima (57210113536)MirásReda, Gianluigi (23467611300)Gianluigi (23467611300)RedaSaghumyan, Gevorg (57320897700)Gevorg (57320897700)SaghumyanShrestha, Amit (57217862157)Amit (57217862157)ShresthaTe Raa, Doreen (56770001000)Doreen (56770001000)Te RaaTonino, Sanne H. (8683505100)Sanne H. (8683505100)ToninoVan Der Spek, Ellen (12774542900)Ellen (12774542900)Van Der Spekvan Gelder, Michel (22954857000)Michel (22954857000)van Geldervan Kampen, Roel (6602972738)Roel (6602972738)van KampenWasik-Szczepanek, Ewa (6602885213)Ewa (6602885213)Wasik-SzczepanekWróbel, Tomasz (57225215444)Tomasz (57225215444)WróbelSegundo, Lucrecia Yáñez San (57218210113)Lucrecia Yáñez San (57218210113)SegundoYassin, Mohamed (36939837900)Mohamed (36939837900)YassinPocali, Barbara (6602561206)Barbara (6602561206)PocaliVandenberghe, Elisabeth (56039020700)Elisabeth (56039020700)VandenbergheIyengar, Sunil (41561525400)Sunil (41561525400)IyengarVarettoni, Marzia (6602800204)Marzia (6602800204)VarettoniVitale, Candida (56694125700)Candida (56694125700)VitaleCoscia, Marta (21736336300)Marta (21736336300)CosciaRambaldi, Alessandro (7005421838)Alessandro (7005421838)RambaldiMontserrat, Emili (55431625100)Emili (55431625100)MontserratCuneo, Antonio (7006208534)Antonio (7006208534)CuneoStavroyianni, Niki (6603584154)Niki (6603584154)StavroyianniTrentin, Livio (7006300206)Livio (7006300206)TrentinStamatopoulos, Kostas (7004539534)Kostas (7004539534)StamatopoulosGhia, Paolo (7006438369)Paolo (7006438369)Ghia2025-06-122025-06-122023https://doi.org/10.1002/ajh.27093https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172666179&doi=10.1002%2fajh.27093&partnerID=40&md5=9b2d9b8d3f544982f58007dd0decc3c7https://remedy.med.bg.ac.rs/handle/123456789/2444In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders (small lymphocytic lymphoma and high-count monoclonal B lymphocytosis) infected by SARS-CoV-2, including the development of post-COVID condition. Data from 1540 patients with CLL infected by SARS-CoV-2 from January 2020 to May 2022 were included in the analysis and assigned to four phases based on cases disposition and SARS-CoV-2 variants emergence. Post-COVID condition was defined according to the WHO criteria. Patients infected during the most recent phases of the pandemic, though carrying a higher comorbidity burden, were less often hospitalized, rarely needed intensive care unit admission, or died compared to patients infected during the initial phases. The 4-month overall survival (OS) improved through the phases, from 68% to 83%, p =.0015. Age, comorbidity, CLL-directed treatment, but not vaccination status, emerged as risk factors for mortality. Among survivors, 6.65% patients had a reinfection, usually milder than the initial one, and 16.5% developed post-COVID condition. The latter was characterized by fatigue, dyspnea, lasting cough, and impaired concentration. Infection severity was the only risk factor for developing post-COVID. The median time to resolution of the post-COVID condition was 4.7 months. OS in patients with CLL improved during the different phases of the pandemic, likely due to the improvement of prophylactic and therapeutic measures against SARS-CoV-2 as well as the emergence of milder variants. However, mortality remained relevant and a significant number of patients developed post-COVID conditions, warranting further investigations. © 2023 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.