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(57685166000)A. (57685166000)HuntThorpe, K. (35425239000)K. (35425239000)ThorpeHardman, C. (57312596100)C. (57312596100)HardmanCusack, E. (57311707600)E. (57311707600)CusackAdams, L. (57685506000)L. (57685506000)AdamsHough, M. (57311707700)M. (57311707700)HoughKeenan, S. (57195550820)S. (57195550820)KeenanBowring, A. (57201067591)A. (57201067591)BowringWatts, J. (57311927900)J. (57311927900)WattsZaman, J. (56377827600)J. (56377827600)ZamanGoffin, K. (57312812000)K. (57312812000)GoffinNutt, H. (57792837000)H. (57792837000)NuttBeerachee, Y. (57213070710)Y. (57213070710)BeeracheeFeatherstone, J. (57313261500)J. (57313261500)FeatherstoneMills, C. (57313034300)C. (57313034300)MillsPearson, J. (57312587200)J. (57312587200)PearsonStephenson, L. (57204249332)L. (57204249332)StephensonGrant, S. (57198160185)S. (57198160185)GrantWilson, A. (59631031000)A. (59631031000)WilsonHawksworth, C. (57207304570)C. (57207304570)HawksworthAlam, I. (57205493251)I. (57205493251)AlamRobinson, M. 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(57684496200)D. (57684496200)SimmonsColes, D. (57312600200)D. (57312600200)ColesCotterill, D. (56868610400)D. (56868610400)CotterillBeech, S. (57311932300)S. (57311932300)BeechKidd, S. (57312379800)S. (57312379800)KiddWrigley, B. (35199378200)B. (35199378200)WrigleyPetkar, S. (8958429800)S. (8958429800)PetkarSmallwood, A. (57312158300)A. (57312158300)SmallwoodJones, R. (10042286500)R. (10042286500)JonesRadford, E. (57311711100)E. (57311711100)RadfordMilgate, S. (57793669400)S. (57793669400)MilgateMetherell, S. (58203479200)S. (58203479200)MetherellCottam, V. (55340845700)V. (55340845700)CottamBuckley, C. (7202815244)C. (7202815244)BuckleyBroadley, A. (57223976576)A. (57223976576)BroadleyWood, D. (58763955500)D. (58763955500)WoodAllison, J. (57684920100)J. (57684920100)AllisonRennie, K. (7004000843)K. (7004000843)RennieBalian, L. (6506569497)L. (6506569497)BalianHoward, L. (57612639400)L. (57612639400)HowardPippard, L. (58284678100)L. (58284678100)PippardBoard, S. (57201075413)S. (57201075413)BoardPitt-Kerby, T. (57195551123)T. (57195551123)Pitt-Kerby2025-06-122025-06-122022https://doi.org/10.1016/j.ejim.2022.01.025https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124269900&doi=10.1016%2fj.ejim.2022.01.025&partnerID=40&md5=c6c71aa989a90f4ec1533ce4731cf00ehttps://remedy.med.bg.ac.rs/handle/123456789/3597Background: Cardiac troponins (cTn) have been reported to be predictors for adverse outcomes in atrial fibrillation (AF), patients, but their actual use is still unclear. Aim: To assess the factors associated with cTn testing in routine practice and evaluate the association with outcomes. Methods: Patients enrolled in the ESC-EHRA EORP-AF General Long-Term Registry were stratified into 3 groups according to cTn levels as (i) cTn not tested, (ii) cTn in range (≤99th percentile), (iii) cTn elevated (>99th percentile). The composite outcome of any thromboembolism /any acute coronary syndrome/cardiovascular (CV) death, defined as Major Adverse Cardiovascular Events (MACE) and all-cause death were the main endpoints. Results: Among 10 445 AF patients (median age 71 years, 40.3% females) cTn were tested in 2834 (27.1%). cTn was elevated in 904/2834 (31.9%) and in-range in 1930/2834 (68.1%) patients. Female sex, in-hospital enrollment, first-detected AF, CV risk factors, history of coronary artery disease, and atypical AF symptoms were independently associated with cTn testing. Elevated cTn were independently associated with a higher risk for MACE (Model 1, hazard ratio [HR] 1.74, 95% confidence interval [CI] 1.40–2.16, Model 2, HR 1.62, 95% CI 1.28–2.05; Model 3 HR 1.76, 95% CI 1.37–2.26) and all-cause death (Model 1, HR 1.45, 95% CI 1.21–1.74; Model 2, HR 1.36, 95% CI 1.12–1.66; Model 3, HR 1.38, 95% CI 1.12–1.71). Conclusions: Elevated cTn levels were associated with an increased risk of all-cause mortality and adverse CV events. Clinical factors that might enhance the need to rule out CAD were associated with cTn testing. © 2022 European Federation of Internal MedicineAF registryAtrial fibrillationBiomarkersDeathMajor adverse cardiovascular eventsoutcomesTroponinsCardiac troponins and adverse outcomes in European patients with atrial fibrillation: A report from the ESC-EHRA EORP atrial fibrillation general long-term registry