Savic, Lidija (16507811000)Lidija (16507811000)SavicMrdovic, Igor (10140828000)Igor (10140828000)MrdovicAsanin, Milika (8603366900)Milika (8603366900)AsaninStankovic, Sanja (7005216636)Sanja (7005216636)StankovicLasica, Ratko (14631892300)Ratko (14631892300)LasicaMatic, Dragan (25959220100)Dragan (25959220100)MaticSimic, Damjan (58010380500)Damjan (58010380500)SimicKrljanac, Gordana (8947929900)Gordana (8947929900)Krljanac2025-06-122025-06-122023https://doi.org/10.3390/jpm13071110https://www.scopus.com/inward/record.uri?eid=2-s2.0-85167844921&doi=10.3390%2fjpm13071110&partnerID=40&md5=fc724d1e560ce72ab9d22a68e6c74871https://remedy.med.bg.ac.rs/handle/123456789/2635Background: We aimed to analyze the prevalence and long-term prognostic impact of non-cardiac comorbidities in patients with reduced and preserved left-ventricular ejection fraction (EF) following ST-elevation myocardial infarction (STEMI). Method: A total of 3033 STEMI patients undergoing primary percutaneous coronary intervention (pPCI) were divided in two groups: reduced EF < 50% and preserved EF ≥ 50%. The follow-up period was 8 years. Results: Preserved EF was present in 1726 (55.4%) patients and reduced EF was present in 1389 (44.5%) patients. Non-cardiac comorbidities were more frequent in patients with reduced EF compared with patients with preserved EF (38.9% vs. 27.4%, respectively, p < 0.001). Lethal outcome was registered in 240 (17.2%) patients with reduced EF and in 40 (2.3%) patients with preserved EF, p < 0.001. Diabetes and chronic kidney disease (CKD) were independent predictors for 8-year mortality in patients with preserved EF. In patients with reduced EF, CKD was independently associated with 8-year mortality. Conclusion: In patients who had reduced EF, the prevalence of non-cardiac comorbidities was higher than in patients who had preserved EF after STEMI. Only diabetes mellitus and CKD were independently associated with 8-year mortality in analyzed patients. © 2023 by the authors.ejection fractionmyocardial infarctionnon-cardiac comorbiditiesprognosis