Gvozdenovic, B.S. (13409361400)B.S. (13409361400)GvozdenovicMihailovic-Vucinic, V. (13410407800)V. (13410407800)Mihailovic-VucinicVukovic, M. (8860387500)M. (8860387500)VukovicLower, E.E. (7003501287)E.E. (7003501287)LowerBaughman, R.P. (7202722744)R.P. (7202722744)BaughmanDudvarski-Ilic, A. (7004055911)A. (7004055911)Dudvarski-IlicZugic, V. (13410862400)V. (13410862400)ZugicPopevic, S. (54420874900)S. (54420874900)PopevicVidenovic-Ivanov, J. (13409677000)J. (13409677000)Videnovic-IvanovFilipovic, S. (13409502500)S. (13409502500)FilipovicStjepanovic, M. (55052044500)M. (55052044500)StjepanovicOmcikus, M. (55632936500)M. (55632936500)Omcikus2025-06-122025-06-122013https://doi.org/10.5588/ijtld.12.0665https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875423592&doi=10.5588%2fijtld.12.0665&partnerID=40&md5=691a1cf82fb57da5fac7b1f64f645d86https://remedy.med.bg.ac.rs/handle/123456789/9230OBJECTIVES: To assess the impact of high body mass index (BMI) on patient-reported outcomes in sarcoidosis patients and healthy persons. METHODS: In this case-control study, we investigated symptoms of fatigue and dyspnoea, health status, BMI and spirometric tests in 184 sarcoidosis patients and the same number of sex- and age-matched healthy subjects. Fatigue was assessed using the fatigue scale (FS), dyspnoea was determined by the baseline dyspnoea index (BDI) and health status was measured using the respiratory-specific St George's Respiratory Questionnaire (SGRQ). RESULTS: There were significantly more subjects with increased BMI (>25 kg /m2) among the sarcoidosis patients than among the healthy volunteers (>237.675, P < 0.01). Sarcoidosis patients also had a greater probability of having a higher BMI (P < 0.01, OR 1.18, 95%CI 1.07-1.3). We found significantly lower BDI scores and forced expiratory volume in 1 s/ forced vital capacity, as well as higher total SGRQ and total FS scores in sarcoidosis patients than in healthy individuals (P < 0.01 for all differences). CONCLUSION: Sarcoidosis significantly reduces patients' health status, both independently and also due to increased BMI. Reduction in BMI may contribute to improved spirometry results and health status of patients with sarcoidosis. © 2013 The Union.Body mass indexDyspnoeaFatigueHealth statusObesityPatientreported outcomesSarcoidosis