Mitrovic, Mirjana (54972086700)Mirjana (54972086700)MitrovicSuvajdzic, Nada (7003417452)Nada (7003417452)SuvajdzicBogdanovic, Andrija (6603686934)Andrija (6603686934)BogdanovicKurtovic, Nada Kraguljac (36195445000)Nada Kraguljac (36195445000)KurtovicSretenovic, Aleksandra (24170024700)Aleksandra (24170024700)SretenovicElezovic, Ivo (12782840600)Ivo (12782840600)ElezovicTomin, Dragica (6603497854)Dragica (6603497854)Tomin2025-06-122025-06-122013https://doi.org/10.1007/s12032-013-0478-yhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84880625846&doi=10.1007%2fs12032-013-0478-y&partnerID=40&md5=28ae6475b24471e97aa7978160925885https://remedy.med.bg.ac.rs/handle/123456789/9236High-hemorrhagic early death (ED) rate is a major impediment in the managing of acute promyelocytic leukemia (APL). In our group of 56 newly diagnosed APL patients, ED occurred in 12 subjects, due to endocranial bleeding (8/12), differentiation syndrome (2/12), or infection (2/12). Predictors of hemorrhagic ED were as follows: white blood cells count ≥20 × 10 9/L (P = 0.002337), Eastern cooperative oncology group performance status ≥3 (P = 0.00173), fibrinogen level <2 g/L (P = 0.004907), prothrombin time <50% (P = 0.0124), and International Society of Thrombosis and Hemostasis Scoring System for disseminated intravascular coagulation (ISTH DIC score) ≥6 (P = 0.00741). Multivariate analysis indicated ISTH DIC score ≥6 to be the most significant predictor for hemorrhagic ED (P = 0.008). The main finding of this study is that simple coagulation-related tests, performed on hospital admission and combined in the ISTH DIC score, might help to identify patients at high risk for fatal bleeding needing more aggressive supportive measures. © 2013 Springer Science+Business Media New York.Acute promyelocytic leukemiaATRAHemorrhagic early deathISTH DIC score