Fitzmaurice, Christina (57212628757)Christina (57212628757)FitzmauriceAkinyemiju, Tomi F. (57202561503)Tomi F. (57202561503)AkinyemijuAl Lami, Faris Hasan (57200737005)Faris Hasan (57200737005)Al LamiAlam, Tahiya (57205589820)Tahiya (57205589820)AlamAlizadeh-Navaei, Reza (36024974700)Reza (36024974700)Alizadeh-NavaeiAllen, Christine (57200170678)Christine (57200170678)AllenAlsharif, Ubai (57211633255)Ubai (57211633255)AlsharifAlvis-Guzman, Nelson (57210741239)Nelson (57210741239)Alvis-GuzmanAmini, Erfan (35073393800)Erfan (35073393800)AminiAnderson, Benjamin O. (22937050900)Benjamin O. (22937050900)AndersonAremu, Olatunde (57214958833)Olatunde (57214958833)AremuArtaman, Al (57217223811)Al (57217223811)ArtamanAsgedom, Solomon Weldegebreal (57203681037)Solomon Weldegebreal (57203681037)AsgedomAssadi, Reza (57203677411)Reza (57203677411)AssadiAtey, Tesfay Me Hari (57209784978)Tesfay Me Hari (57209784978)AteyAvila-Burgos, Leticia (8530790100)Leticia (8530790100)Avila-BurgosAwasthi, Ashish (58420926700)Ashish (58420926700)AwasthiSaleem, Huda Omerba (57211004875)Huda Omerba (57211004875)SaleemBarac, Aleksandra (55550748700)Aleksandra (55550748700)BaracBennett, James R. (59110116800)James R. (59110116800)BennettBensenor, Isabela M. (7004830338)Isabela M. (7004830338)BensenorBhakta, Nickhill (55503867200)Nickhill (55503867200)BhaktaBrenner, Hermann (7201832825)Hermann (7201832825)BrennerCahuana-Hurtado, Lucero (57207890731)Lucero (57207890731)Cahuana-HurtadoCastañeda-Orjuela, Carlos A. (35769124700)Carlos A. (35769124700)Castañeda-OrjuelaCatalá-López, Ferrán (57202553733)Ferrán (57202553733)Catalá-LópezChoi, Jee-Young Jasmine (57209706428)Jee-Young Jasmine (57209706428)ChoiChristopher, Devasahayam Jesudas (57209863533)Devasahayam Jesudas (57209863533)ChristopherChung, Sheng-Chia (56008137900)Sheng-Chia (56008137900)ChungCurado, Maria Paula (6603824212)Maria Paula (6603824212)CuradoDandona, Lalit (7007017243)Lalit (7007017243)DandonaDandona, Rakhi (57203043697)Rakhi (57203043697)DandonaDas Neves, José (57208073193)José (57208073193)Das NevesDey, Subhojit (25958052600)Subhojit (25958052600)DeyDharmaratne, Samath D. (57216324802)Samath D. (57216324802)DharmaratneDoku, David Teye (36015210300)David Teye (36015210300)DokuDriscoll, Tim R. (7005928308)Tim R. (7005928308)DriscollDubey, Manisha (57219898654)Manisha (57219898654)DubeyEbrahimi, Hedyeh (57195329214)Hedyeh (57195329214)EbrahimiEdessa, Dumessa (56922334200)Dumessa (56922334200)EdessaEl-Khatib, Ziad (54908919000)Ziad (54908919000)El-KhatibEndries, Aman Yesuf (57216324852)Aman Yesuf (57216324852)EndriesFischer, Florian (55508208800)Florian (55508208800)FischerForce, Lisa M. (57188548035)Lisa M. (57188548035)ForceForeman, Kyle J. (57209064414)Kyle J. (57209064414)ForemanGebrehiwot, Solomon Weldemariam (57194550425)Solomon Weldemariam (57194550425)GebrehiwotGopalani, Sameer Vali (57190277891)Sameer Vali (57190277891)GopalaniGrosso, Giuseppe (57196998256)Giuseppe (57196998256)GrossoGupta, Rahul (57204120071)Rahul (57204120071)GuptaGyawali, Bishal (56237046200)Bishal (56237046200)GyawaliHamadeh, Randah Ribhi (57202769526)Randah Ribhi (57202769526)HamadehHamidi, Samer (24366336000)Samer (24366336000)HamidiHarvey, James (57196074369)James (57196074369)HarveyHassen, Hamid Yimam (57188660707)Hamid Yimam (57188660707)HassenHay, Roderick J. (56785229200)Roderick J. (56785229200)HayHay, Simon I. (7101875313)Simon I. (7101875313)HayHeibati, Behzad (55341086000)Behzad (55341086000)HeibatiHiluf, Molla Kahssay (57201396270)Molla Kahssay (57201396270)HilufHorita, Nobuyuki (57217110823)Nobuyuki (57217110823)HoritaHosgood, H. Dean (56353204400)H. Dean (56353204400)HosgoodIlesanmi, Olayinka S. (54782692800)Olayinka S. (54782692800)IlesanmiInnos, Kaire (57217314902)Kaire (57217314902)InnosIslami, Farhad (56926442900)Farhad (56926442900)IslamiJakovljevic, Mihajlo B. (14318929700)Mihajlo B. (14318929700)JakovljevicJohnson, Sarah Charlotte (57207904886)Sarah Charlotte (57207904886)JohnsonJonas, Jost B. (7202492953)Jost B. (7202492953)JonasKasaeian, Amir (57195540738)Amir (57195540738)KasaeianKassa, Tesfaye Dessale (58686045600)Tesfaye Dessale (58686045600)KassaKhader, Yousef Saleh (55654192600)Yousef Saleh (55654192600)KhaderKhan, Ejaz Ahmad (57218791274)Ejaz Ahmad (57218791274)KhanKhan, Gulfaraz (6701635515)Gulfaraz (6701635515)KhanKhang, Young-Ho (57198904674)Young-Ho (57198904674)KhangKhosravi, Mohammad Hossein (56524167000)Mohammad Hossein (56524167000)KhosraviKhubchandani, Jagdish (57211720011)Jagdish (57211720011)KhubchandaniKopec, Jacek A. (7006284395)Jacek A. (7006284395)KopecKumar, G. Anil (57139550500)G. Anil (57139550500)KumarKutz, Michael (57195617315)Michael (57195617315)KutzLad, Deepesh Pravinkumar (55371865400)Deepesh Pravinkumar (55371865400)LadLafranconi, Alessandra (55767061200)Alessandra (55767061200)LafranconiLan, Qing (23970641100)Qing (23970641100)LanLegesse, Yirga (57202220147)Yirga (57202220147)LegesseLeigh, James (7202089604)James (7202089604)LeighLinn, Shai (7102590173)Shai (7102590173)LinnLunevicius, Raimundas (57216165063)Raimundas (57216165063)LuneviciusMajeed, Azeem (7102027801)Azeem (7102027801)MajeedMalekzadeh, Reza (7005197760)Reza (7005197760)MalekzadehMalta, Deborah Carvalho (15835283500)Deborah Carvalho (15835283500)MaltaMantovani, Lorenzo G. (7006357517)Lorenzo G. (7006357517)MantovaniMcMahon, Brian J. (56713188900)Brian J. (56713188900)McMahonMeier, Toni (36678887300)Toni (36678887300)MeierMelaku, Yohannes Adama (57203122720)Yohannes Adama (57203122720)MelakuMelku, Mulugeta (56032188500)Mulugeta (56032188500)MelkuMemiah, Peter (57217207827)Peter (57217207827)MemiahMendoza, Walter (57216905642)Walter (57216905642)MendozaMeretoja, Tuomo J. (57202554188)Tuomo J. (57202554188)MeretojaMezgebe, Haftay Berhane (57222113213)Haftay Berhane (57222113213)MezgebeMiller, Ted R. (7403948600)Ted R. (7403948600)MillerMohammed, Shafiu (57838689000)Shafiu (57838689000)MohammedMokdad, Ali H. (7004813962)Ali H. (7004813962)MokdadMoosazadeh, Mahmood (35771326500)Mahmood (35771326500)MoosazadehMoraga, Paula (46761426800)Paula (46761426800)MoragaMousavi, Seyyed Meysam (56165159700)Seyyed Meysam (56165159700)MousaviNangia, Vinay (57201490837)Vinay (57201490837)NangiaNguyen, Cuong Tat (56531347200)Cuong Tat (56531347200)NguyenNong, Vuong Minh (55507077200)Vuong Minh (55507077200)NongOgbo, Felix Akpojene (57200737136)Felix Akpojene (57200737136)OgboOlagunju, Andrew Toyin (26029995700)Andrew Toyin (26029995700)OlagunjuMahesh, P.A. (57202421244)P.A. (57202421244)MaheshPark, Eun-Kee (57216814178)Eun-Kee (57216814178)ParkPatel, Tejas (57207871841)Tejas (57207871841)PatelPereira, David M. (57200690024)David M. (57200690024)PereiraPishgar, Farhad (56676403900)Farhad (56676403900)PishgarPostma, Maarten J. (7006296502)Maarten J. (7006296502)PostmaPourmalek, Farshad (8309390500)Farshad (8309390500)PourmalekQorbani, Mostafa (24831040300)Mostafa (24831040300)QorbaniRafay, Anwar (57212263323)Anwar (57212263323)RafayRawaf, Salman (6602475959)Salman (6602475959)RawafRawaf, David Laith (57209228052)David Laith (57209228052)RawafRoshandel, Gholamreza (14034446800)Gholamreza (14034446800)RoshandelSafiri, Saeid (56009654100)Saeid (56009654100)SafiriSalimzadeh, Hamideh (23052386900)Hamideh (23052386900)SalimzadehSanabria, Juan Ramon (7006262917)Juan Ramon (7006262917)SanabriaMilicevic, Milena M. Santric (57209748201)Milena M. Santric (57209748201)MilicevicSartorius, Benn (12788526800)Benn (12788526800)SartoriusSatpathy, Maheswar (57202563691)Maheswar (57202563691)SatpathySepanlou, Sadaf G. (36248136000)Sadaf G. (36248136000)SepanlouShackelford, Katya Anne (57202959163)Katya Anne (57202959163)ShackelfordShaikh, Masood Ali (57203122601)Masood Ali (57203122601)ShaikhSharif-Alhoseini, Mahdi (35108018000)Mahdi (35108018000)Sharif-AlhoseiniShe, Jun (57209122131)Jun (57209122131)SheShin, Min-Jeong (7401536640)Min-Jeong (7401536640)ShinShiue, Ivy (35811219800)Ivy (35811219800)ShiueShrime, Mark G. (57204703404)Mark G. (57204703404)ShrimeSinke, Abiy Hiruye (57195329519)Abiy Hiruye (57195329519)SinkeSisay, Mekonnen (57193254700)Mekonnen (57193254700)SisaySligar, Amber (57190284582)Amber (57190284582)SligarSufiyan, Muawiyyah Babale (58294633600)Muawiyyah Babale (58294633600)SufiyanSykes, Bryan L. (57211183396)Bryan L. (57211183396)SykesTabarés-Seisdedos, Rafael (6602981102)Rafael (6602981102)Tabarés-SeisdedosTessema, Gizachew Assefa (57196316304)Gizachew Assefa (57196316304)TessemaTopor-Madry, Roman (57211182892)Roman (57211182892)Topor-MadryTran, Tung Thanh (57199423355)Tung Thanh (57199423355)TranTran, Bach Xuan (57209107515)Bach Xuan (57209107515)TranUkwaja, Kingsley Nnanna (57202824584)Kingsley Nnanna (57202824584)UkwajaVlassov, Vasiliy Victorovich (57211633239)Vasiliy Victorovich (57211633239)VlassovVollset, Stein Emil (57196315778)Stein Emil (57196315778)VollsetWeiderpass, Elisabete (57205018947)Elisabete (57205018947)WeiderpassWilliams, Hywel C. (23500447000)Hywel C. (23500447000)WilliamsYimer, Nigus Bililign (57216264444)Nigus Bililign (57216264444)YimerYonemoto, Naohiro (57204947657)Naohiro (57204947657)YonemotoYounis, Mustafa Z. (8549393000)Mustafa Z. (8549393000)YounisMurray, Christopher J. L. (55481130700)Christopher J. L. (55481130700)MurrayNaghavi, Mohsen (57207906323)Mohsen (57207906323)Naghavi2025-06-122025-06-122018https://doi.org/10.1001/jamaoncol.2018.2706https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055941761&doi=10.1001%2fjamaoncol.2018.2706&partnerID=40&md5=11b6476af77e1dd805b44c219878303ahttps://remedy.med.bg.ac.rs/handle/123456789/6063IMPORTANCE: The increasing burden due tocancer and other noncommunicable diseases poses a threat to human development, which has resulted in global political commitments reflected in the Sustainable Development Goals as well as the World Health Organization (WHO) GlobalAction Plan on Non-Communicable Diseases. To determine if these commitments have resulted in improved cancer control, quantitative assessments of the cancer burden are required. OBJECTIVE: To assess the burden for 29 cancer groups over time to provide a framework for policy discussion, resource allocation, and research focus. EVIDENCE REVIEW: Cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs) were evaluated for 195 countries and territories by age and sex using the Global Burden of Disease study estimation methods. Levels and trends were analyzed over time, as well as by the Sociodemographic Index (SDI). Changes in incident cases were categorized by changes due to epidemiological vs demographic transition. FINDINGS: In 2016, there were 17.2 million cancer cases worldwide and 8.9 million deaths. Cancer cases increased by 28% between 2006 and 2016. The smallestincrease was seen in high SDI countries. Globally, population aging contributed 17%; population growth, 12%; and changes in age-specific rates, -1% to this change. The most common incident cancer globally for men was prostate cancer (1.4 million cases). The leading cause of cancer deaths and DALYs was tracheal, bronchus, and lung cancer (1.2 million deaths and 25.4 million DALYs). For women, the most common incident cancer and the leading cause ofcancer deaths and DALYs was breast cancer (1.7 million incident cases, 535 000 deaths, and 14.9 million DALYs). In 2016, cancer caused 213.2 million DALYs globally for both sexes combined. Between 2006 and 2016, the average annual age-standardized incidence rates for all cancers combined increased in 130 of 195 countries or territories, and the average annual age-standardized death rates decreased within that timeframe in 143 of 195 countries or territories. CONCLUSIONS AND RELEVANCE: Large disparities exist between countries in cancer incidence, deaths, and associated disability. Scaling up cancer prevention and ensuring universal access to cancer care are required for health equity and to fulfill the global commitments for noncommunicable disease and cancer control. © 2018 American Medical Association. All rights reserved.