Bumbasirevic, Vesna (8915014500)Vesna (8915014500)BumbasirevicRadenkovic, Dejan (6603592685)Dejan (6603592685)RadenkovicJankovic, Zorica (8279037500)Zorica (8279037500)JankovicKaramarkovic, Aleksandar (6507164080)Aleksandar (6507164080)KaramarkovicJovanovic, Bojan (35929424700)Bojan (35929424700)JovanovicMilic, Natasa (7003460927)Natasa (7003460927)MilicPalibrk, Ivan (6507415211)Ivan (6507415211)PalibrkIvancevic, Nenad (24175884900)Nenad (24175884900)Ivancevic2025-07-022025-07-022009https://doi.org/10.1097/MPA.0b013e31818a392fhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-65349108046&doi=10.1097%2fMPA.0b013e31818a392f&partnerID=40&md5=bb9e2a0ca69fd7568e3856e3634dd5fchttps://remedy.med.bg.ac.rs/handle/123456789/14166OBJECTIVES: To determine overall mortality and timing of death in patients with severe acute pancreatitis and factors affecting mortality. METHODS: This was a retrospective, observational study of 110 patients admitted to a general intensive care unit (ICU) from January 2003 to January 2006. RESULTS: The overall mortality rate was 53.6% (59/110); 25.4% (n = 15) of deaths were early (≤14 days after ICU admission). There were no significant differences in age, sex, or surgical/medical treatment between survivors and nonsurvivors. Median Acute Physiology and Chronic Health Evaluation (APACHE) II score was higher among nonsurvivors than survivors (score = 26 vs 19, respectively; P < 0.001), and the duration of hospitalization before ICU admission was significantly longer (4 vs 1 day; P < 0.001). Among the 59 patients who died, those in the early-mortality group were admitted to the ICU significantly earlier than those in the late-mortality group (3 vs 6.5 days; P < 0.05). CONCLUSIONS: Overall mortality and median APACHE II score were high. Death predominantly occurred late and was unaffected by patient age, length of stay in the ICU, or surgical/medical treatment. An APACHE II cutoff of 24.5 and pre-ICU admission time of 2.5 days were sensitive predictors of fatal outcome. Copyright © 2009 by Lippincott Williams & Wilkins.Acute pancreatitisIntensive care unitMortalitySepsis