Jovanovic, Ljiljana (57206262537)Ljiljana (57206262537)JovanovicSubota, Vesna (16319788700)Vesna (16319788700)SubotaStavric, Milena (57206254620)Milena (57206254620)StavricSubotic, Bojana (57191374758)Bojana (57191374758)SuboticDzudovic, Boris (55443513300)Boris (55443513300)DzudovicNovicic, Natasa (57206272531)Natasa (57206272531)NovicicMatijasevic, Jovan (35558899700)Jovan (35558899700)MatijasevicMiric, Milica (57193772097)Milica (57193772097)MiricSalinger, Sonja (15052251700)Sonja (15052251700)SalingerMarkovic-Nikolic, Natasa (57211527501)Natasa (57211527501)Markovic-NikolicNikolic, Maja (57206239238)Maja (57206239238)NikolicMiloradovic, Vladimir (8355053500)Vladimir (8355053500)MiloradovicKos, Ljiljana (57206257234)Ljiljana (57206257234)KosKovacevic-Preradovic, Tamara (21743080300)Tamara (21743080300)Kovacevic-PreradovicMarinkovic, Jelena (7004611210)Jelena (7004611210)MarinkovicKocev, Nikola (6602672952)Nikola (6602672952)KocevObradovic, Slobodan (6701778019)Slobodan (6701778019)Obradovic2025-07-022025-07-022019https://doi.org/10.1016/j.cca.2019.02.008https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061634751&doi=10.1016%2fj.cca.2019.02.008&partnerID=40&md5=e37450c9032796978252d396a1219f16https://remedy.med.bg.ac.rs/handle/123456789/12709Factors associated with provoked PE may influence a biomarker's predictive value for the primary outcome. The aim of this study was to investigate the value of BNP, cTnI, CRP and D-Dimer measurements taken soon after hospital admission for the prediction of 30-day PE-caused death in patients with spontaneous versus provoked PE.Data were extracted from a pool of 726 consecutive PE patients enrolled in the multicenter Serbian PE registry. Blood concentrations of BNP, cTnI, CRP and D-dimer were measured during the first 24 h of hospitalization. BNP blood level had strong predictive value for the primary outcome in spontaneous PE (c-statistics 0.943, 95% CI 0.882–1.000, p = .001) and a slightly lower predictive outcome in provoked PE (c-statistics 0.824, 95% CI 0.745–0.902, p < .001). NRI and IDI showed that none of the markers, when added to BNP, could improve Cox regression prediction models for 30-day PE-related mortality in either the spontaneous or provoked PE group. Blood levels of BNP measured during the first 24 h of hospital admission had an excellent predictive value for 30-day PE-related mortality in spontaneous PE and slightly lower predictive value in provoked PE, whereas CRP, cTnI and D-Dimer did not contribute significantly to the predictive value of BNP in either group. © 2019 Elsevier B.V.BiomarkersBrain natriuretic peptideMortalityPulmonary embolism