Sreckovic, Svetlana (55979299300)Svetlana (55979299300)SreckovicLadjevic, Nebojsa (16233432900)Nebojsa (16233432900)LadjevicMilicic, Biljana (6603829143)Biljana (6603829143)MilicicTulic, Goran (23036995600)Goran (23036995600)TulicMilovanovic, Darko (37063548000)Darko (37063548000)MilovanovicDjukanovic, Marija (56946634400)Marija (56946634400)DjukanovicKadija, Marko (16063920000)Marko (16063920000)Kadija2025-06-122025-06-122023https://doi.org/10.3389/fmed.2023.1335405https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183022861&doi=10.3389%2ffmed.2023.1335405&partnerID=40&md5=89e4419fde2709afdd1000bd106c2a3fhttps://remedy.med.bg.ac.rs/handle/123456789/2870Introduction: Peripheral nerve blocks are an efficient method of pain control after total knee arthroplasty (TKA), but there is no report of their impact on chronic post-surgical pain (CPSP). Methods: This prospective observational study aimed to assess adductor canal block (ACB) and IPACK block (blocks vs. no blocks) on opioid consumption, postoperative pain score, chronic post-surgical pain 2 years after TKA. Results: 166 patients (82 vs. 84) were analyzed. Opioid consumption was less in the group with blocks (9.74 ± 3.87 mg vs. 30.63 ± 11.52 mg) (p < 0.001). CPSP was present in 20.24% of patients in the group without blocks and 6.1% of patients with blocks (p = 0.011). Predictor variables of CPSP included pain before surgery (cut-off of 5.5), pain at rest (cut-off of 2.35), pain during active movement (cut-off: 2.5), and opioid consumption (cut-off: 8 mg). Conclusion: Peripheral nerve blocks provide adequate analgesia, significantly decrease opioid consumption, improve functional outcomes, and reduce CPSP 2 years after surgery. Copyright © 2024 Sreckovic, Ladjevic, Milicic, Tulic, Milovanovic, Djukanovic and Kadija.adductor canal blockchronic painIPACK blockknee arthroplastyperipheral nerve block