Melanoma tumor inhibition by tetrachlorido(O,O′-dibutyl- ethylenediamine-N,N′-di-3-propionate)platinum(iv) complex: In vitro and in vivo investigations

Maksimović-Ivanić, Danijela (6507584634)Danijela (6507584634)Maksimović-IvanićMijatović, Sanja (6508347659)Sanja (6508347659)MijatovićMirkov, Ivana (23973384600)Ivana (23973384600)MirkovStošić-Grujičić, Stanislava (7004253020)Stanislava (7004253020)Stošić-GrujičićMiljković, Djordje (7006524033)Djordje (7006524033)MiljkovićSabo, Tibor J. (7004201321)Tibor J. (7004201321)SaboTrajković, Vladimir (7004516866)Vladimir (7004516866)TrajkovićKaluerović, Goran N. (7801430570)Goran N. (7801430570)Kaluerović2025-06-122025-06-122012https://doi.org/10.1039/c2mt20150jhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84867870472&doi=10.1039%2fc2mt20150j&partnerID=40&md5=1709355129f84460b906f9dda61b02eehttps://remedy.med.bg.ac.rs/handle/123456789/9783Tetrachlorido(O,O′-dibutyl-ethylenediamine-N,N′-di-3- propionate)platinum(iv) complex, [PtCl4(n-Bu2eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu2eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu2eddp)] concealed the expansion of tumors induced in syngeneic C57Bl/6 mice without visible signs of nephrotoxicity. © The Royal Society of Chemistry 2012.Melanoma tumor inhibition by tetrachlorido(O,O′-dibutyl- ethylenediamine-N,N′-di-3-propionate)platinum(iv) complex: In vitro and in vivo investigations