Milenković, Svetlana (57210676212)Svetlana (57210676212)MilenkovićJankovic, Borisav (7005898688)Borisav (7005898688)JankovicMirković, Ljiljana (23474551800)Ljiljana (23474551800)MirkovićJovandaric, Miljana Z. (56748058300)Miljana Z. (56748058300)JovandaricMilenković, Dušan (58422958000)Dušan (58422958000)MilenkovićOtašević, Biljana (57191100883)Biljana (57191100883)Otašević2025-06-122025-06-122017https://doi.org/10.1080/15513815.2016.1242675https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994887834&doi=10.1080%2f15513815.2016.1242675&partnerID=40&md5=883bfc3cd9b180c5b25633c424487edbhttps://remedy.med.bg.ac.rs/handle/123456789/7062Background: Intrauterine growth restriction (IUGR) is a risk factor for developing metabolic syndrome later in life. We explored whether adipokine concentrations in cord blood (CB) and on day 3 (D3) were related to impaired fetal growth and lipids in IUGR twins. Patients and methods: Thirty-six discordant (birth weight [BW] discordance ≥20% calculated in relation to the heavier co-twins) and 42 concordant (BW discordance ≤ 10%) twin pairs were included. Results: In IUGR twins, both adiponectin/BW and triglyceride (TG) levels were significantly higher, while total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol were lower in CB. On D3, both leptin and HDL-C levels were significantly lower and TG levels were significantly higher in IUGR twins. In the discordant group, the alterations in lipids were not related to any adipokine. Conclusions: IUGR is related to lower leptin level and proatherogenic lipid profile (higher TG and lower HDL-C), which are not influenced by adipokine at birth. © 2017 Taylor & Francis Group, LLC.adiponectinCord bloodfetal programmingIUGRleptinlipids