Jankovic, Aleksandar (55908877300)Aleksandar (55908877300)JankovicMaslarevic-Radovic, Vesna (57193504963)Vesna (57193504963)Maslarevic-RadovicDjuric, Petar (56979881000)Petar (56979881000)DjuricTosic-Dragovic, Jelena (57192300480)Jelena (57192300480)Tosic-DragovicBulatovic, Ana (35736942600)Ana (35736942600)BulatovicSimovic, Nikola (57193497147)Nikola (57193497147)SimovicMitrovic, Milos (56979859800)Milos (56979859800)MitrovicStankovic-Popovic, Verica (24399947500)Verica (24399947500)Stankovic-PopovicDopudja-Pantic, Vesna (6507376889)Vesna (6507376889)Dopudja-PanticArandjelovic, Snezana (19533573900)Snezana (19533573900)ArandjelovicDimkovic, Nada (6603958094)Nada (6603958094)Dimkovic2025-07-022025-07-022017https://doi.org/10.3389/fimmu.2017.00111https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014318919&doi=10.3389%2ffimmu.2017.00111&partnerID=40&md5=4e2caee4f4e7e10d3457b9c19cc2d6behttps://remedy.med.bg.ac.rs/handle/123456789/13222Introduction: Microscopic polyangiitis (MPA) is one of the causes of the pulmonary-renal syndrome associated with elevated non-specific markers of inflammation and antineutrophil cytoplasmic autoantibody (ANCA) positivity in 50-75%. De novo occurrence of the disease in patients on chronic hemodialysis (HD) has not been described. Case presentation: We presented patient who developed MPO-ANCA-associated MPA with lung and musculoskeletal involvement after 4 years on regular HD due to bilateral nephrectomy. After excluding the other causes of MPO-ANCA positivity, diagnosis was confirmed even without renal biopsy. Patient received standard immunosuppression therapy and he is still in remission after 27 months. Conclusion: The onset of immune-mediated disease could be observed even after introduction of renal replacement therapy, which may be a diagnostic problem. Early recognition and traditional immunosuppressive regiment may provide successful outcome. © 2017 Jankovic, Maslarevic-Radovic, Djuric, Tosic-Dragovic, Bulatovic, Simovic, Mitrovic, Stankovic-Popovic, Dopudja-Pantic, Arandjelovic and Dimkovic.BinephrectomyChronic hemodialysisMicroscopic polyangiitisMPO-ANCAPulmo