Todorović-Tirnanić, Mila (12772684600)Mila (12772684600)Todorović-TirnanićArtiko, Vera (55887737000)Vera (55887737000)ArtikoPavlović, Smiljana (57225355345)Smiljana (57225355345)PavlovićŠobić-Šaranović, Dragana (57202567582)Dragana (57202567582)Šobić-ŠaranovićObradović, Vladimir (7003389726)Vladimir (7003389726)Obradović2025-06-122025-06-122015https://doi.org/10.2298/SARH1502108Thttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84924408478&doi=10.2298%2fSARH1502108T&partnerID=40&md5=2c68ad69f642fbf7902870e316d520afhttps://remedy.med.bg.ac.rs/handle/123456789/8527The new positron emission tomography (PET/CT) methods for neuroendocrine tumors detection are presented and compared with classic, conventional methods. Conventional methods use a gamma scintillation camera for patients with neuroendocrine tumor imaging, after intravenous injection of one of the following radiopharmaceuticals: 1) somatostatin analogues labeled with indium-111 (111In-pentetreotide) or technetium-99m (99mTc-EDDA/HYNIC-TOC); 2) noradrenaline analogue labeled with iodine-131 or -123 (131I/123I-MIBG); or 3)99mTc(V)-DMSA. Contemporary methods use PET/CT equipment for patients with neuroendocrine tumor imaging, after intravenous injection of pharmaceuticals labeled with positron emitters [fluorine-18 (18F), galium-68 (68Ga), or carbon-11 (11C)]: 1) glucose analogue (18FDG); 2) somatostatin analogue (68Ga-DOTATOC/68Ga-DOTATATE/68Ga-DOTANOC); 3) aminoacid precursors of bioamines: [a) dopamine precursor18F-DOPA (6-18F-dihydroxyphenylalanine), b) serotonin precursor11C-5HTP (11C-5-hydroxytryptophan)]; or 4) dopamine analogue 18F-DA (6-18F-fluorodopamine). Conventional and contemporary (PET/ CT) somatostatin receptor detection showed identical high specificity (92%), but conventional had very low sensitivity (52%) compared to PET/CT (97%). It means that almost every second neuroendocrine tumor detected by contemporary method cannot be discovered using conventional (classic) method. In metastatic pheochromocytoma detection contemporary (PET/ CT) methods (18F-DOPA and18F-DA) have higher sensitivity than conventional (131I/123I-MIBG). In medullary thyroid carcinoma diagnostics contemporary method (18F-DOPA) is more sensitive than conventional 99mTc(V)-DMSA method, and is similar to 18FDG, computed tomography and magnetic resonance. In carcinoid detection contemporary method (18F-DOPA) shows similar results with contemporary somatostatin receptor detection, while for gastroenteropancreatic neuroendocrine tumors it is worse. To conclude, contemporary (PET/CT) methods for somatostatin receptor detection (68Ga-DOTATOC/-NOC/-TATE) in neuroendocrine tumors are much more sensitive (almost twice) and more accurate than conventional. Therefore the classical methods should be urgently replaced by contemporary methods.¹¹C-5-hydroxytryptophan¹⁸F-DOPA¹⁸FDG⁶⁸Ga-DOTATOC6-¹⁸F-fluorodopamineNeuroendocrine tumors