Jovanovic, M. (57212520796)M. (57212520796)JovanovicSoldatovic, I. (35389846900)I. (35389846900)SoldatovicJanjic, A. (57193440245)A. (57193440245)JanjicVuksanovic, A. (6602999284)A. (6602999284)VuksanovicDzamic, Z. (6506981365)Z. (6506981365)DzamicAcimovic, M. (6508256624)M. (6508256624)AcimovicHadzi-Djokic, J. (6603561960)J. (6603561960)Hadzi-Djokic2025-06-122025-06-122011https://doi.org/10.1159/000330246https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052743193&doi=10.1159%2f000330246&partnerID=40&md5=3ceebc86d68c77eac2d46a4144fc4f8dhttps://remedy.med.bg.ac.rs/handle/123456789/10023Objective: To investigate the diagnostic value of the nuclear matrix protein 22 (NMP22) test in comparison to urine cytology for the detection of upper tract urothelial carcinoma. Patients and Methods: Patients with transitional cell carcinoma of the upper urinary tract (n = 34) and patients with renal calculosis (n = 25) were included in this study. Voided urine samples and separated catheter urine specimens were assayed for NMP22 and cytological examination. Results: The sensitivity of the NMP22 test in separated and voided urine was 73.2 and 70.5%, respectively, compared to 64.7 and 58.8% of urine cytology. The specificity of the NMP22 test in separated and voided urine was 88 and 92%, respectively, compared to 96 and 96% of urine cytology. The combination of separated and voided urine is the best method because the sensitivity is 79.41% and specificity 88%. There is a high agreement of the NMP22 test in voided and separated urine (kappa = 0.795, p < 0.01), indicating that the voided urine is adequate for diagnosis. Conclusions: The NMP22 test has higher sensitivity but lower specificity than cytology. The combination of these two tests could be a very useful diagnostic method for detection of upper urothelial tumors. Copyright © 2011 S. Karger AG, Basel.CytologyNuclear matrix protein 22Upper urothelial tumor