Moberg, Madeline E. (57820324700)Madeline E. (57820324700)MobergHamilton, Erin B (57212513365)Erin B (57212513365)HamiltonZeng, Scott M (57218797657)Scott M (57218797657)ZengBryazka, Dana (57200015057)Dana (57200015057)BryazkaZhao, Jeff T (57221069965)Jeff T (57221069965)ZhaoFeldman, Rachel (57204568514)Rachel (57204568514)FeldmanAbate, Yohannes Habtegiorgis (58492166600)Yohannes Habtegiorgis (58492166600)AbateAbbasi-Kangevari, Mohsen (57193543882)Mohsen (57193543882)Abbasi-KangevariAbdurehman, Ame Mehadi (58660534900)Ame Mehadi (58660534900)AbdurehmanAbedi, Aidin (56673854800)Aidin (56673854800)AbediAbu-Gharbieh, Eman (24586714800)Eman (24586714800)Abu-GharbiehAdepoju, Abiola Victor (57201300225)Abiola Victor (57201300225)AdepojuAdnani, Qorinah Estiningtyas Sakilah (57211604149)Qorinah Estiningtyas Sakilah (57211604149)AdnaniAfzal, Saira (7004381116)Saira (7004381116)AfzalAhmad, Sajjad (57218961022)Sajjad (57218961022)AhmadAhmed, Danial (57899140300)Danial (57899140300)AhmedAhmed, Haroon (57222316680)Haroon (57222316680)AhmedAlem, Dejene Tsegaye (57440923600)Dejene Tsegaye (57440923600)AlemAl-Gheethi, Adel Ali Saeed (57195533166)Adel Ali Saeed (57195533166)Al-GheethiAlimohamadi, Yousef (56069375900)Yousef (56069375900)AlimohamadiAmeyaw, Edward Kwabena (57194076624)Edward Kwabena (57194076624)AmeyawAmrollahi-Sharifabadi, Mohammad (56012020500)Mohammad (56012020500)Amrollahi-SharifabadiAnagaw, Tadele Fentabil (57808432800)Tadele Fentabil (57808432800)AnagawAnyasodor, Anayochukwu Edward (57192947419)Anayochukwu Edward (57192947419)AnyasodorArabloo, Jalal (57208760927)Jalal (57208760927)ArablooAravkin, Aleksandr Y (35386103000)Aleksandr Y (35386103000)AravkinAthari, Seyyed Shamsadin (26653399600)Seyyed Shamsadin (26653399600)AthariAtreya, Alok (55856196800)Alok (55856196800)AtreyaJafari, Amirhossein Azari (56084531100)Amirhossein Azari (56084531100)JafariBadiye, Ashish D (56340201200)Ashish D (56340201200)BadiyeBaghcheghi, Nayereh (35092167000)Nayereh (35092167000)BaghcheghiBagherieh, Sara 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(24829099800)HostiucHoveidamanesh, Soodabeh (57201943166)Soodabeh (57201943166)HoveidamaneshIlesanmi, Olayinka Stephen (54782692800)Olayinka Stephen (54782692800)IlesanmiIlic, Irena M (57210823522)Irena M (57210823522)IlicImmurana, Mustapha (57215875071)Mustapha (57215875071)ImmuranaIwu, Chidozie C D (57204657478)Chidozie C D (57204657478)IwuJayarajah, Umesh (57192238672)Umesh (57192238672)JayarajahJoseph, Nitin (35292547200)Nitin (35292547200)JosephJoshua, Charity Ehimwenma (58491197900)Charity Ehimwenma (58491197900)JoshuaKadashetti, Vidya (56724219200)Vidya (56724219200)KadashettiKanchan, Tanuj (35237157900)Tanuj (35237157900)KanchanKandel, Himal (57226834655)Himal (57226834655)KandelKantar, Rami S (56719718400)Rami S (56719718400)KantarKapoor, Neeti (56340726700)Neeti (56340726700)KapoorKaraye, Ibraheem M (55598638900)Ibraheem M (55598638900)KarayeKatoto, Patrick Dmc (57202776078)Patrick Dmc (57202776078)KatotoKhajuria, Himanshu (56639982500)Himanshu (56639982500)KhajuriaKhan, Ejaz Ahmad (57218791274)Ejaz Ahmad (57218791274)KhanKhateri, Sorour (57192959720)Sorour (57192959720)KhateriKhodamoradi, Farzad (57204432429)Farzad (57204432429)KhodamoradiKhormali, Moein (57193114653)Moein (57193114653)KhormaliKhubchandani, Jagdish (57211720011)Jagdish (57211720011)KhubchandaniKim, Grace (57204812303)Grace (57204812303)KimKisa, Adnan (6603346067)Adnan (6603346067)KisaKoohestani, Hamid Reza (26423051700)Hamid Reza (26423051700)KoohestaniKrishan, Kewal (57202279708)Kewal (57202279708)KrishanKumar, Naveen (59222258800)Naveen (59222258800)KumarLaflamme, Lucie (7005939330)Lucie (7005939330)LaflammeLandires, Iván (15063040000)Iván (15063040000)LandiresLarijani, Bagher (57205307740)Bagher (57205307740)LarijaniLauriola, Paolo (7004129174)Paolo (7004129174)LauriolaLe, Thao Thi Thu (57736182100)Thao Thi Thu (57736182100)LeLedda, Caterina (54885410300)Caterina (54885410300)LeddaLee, Seung Won (57223118056)Seung Won (57223118056)LeeLim, Stephen S (57201800433)Stephen S (57201800433)LimLobo, Stany W (58359238600)Stany W (58359238600)LoboLunevicius, Raimundas (57216165063)Raimundas (57216165063)LuneviciusMaharaj, Sandeep B (54883987800)Sandeep B (54883987800)MaharajMenezes, Ritesh G (55517099900)Ritesh G (55517099900)MenezesMentis, Alexios-Fotios A (7003278838)Alexios-Fotios A (7003278838)MentisMestrovic, Tomislav (6507240107)Tomislav (6507240107)MestrovicMiller, Ted R (7403948600)Ted R (7403948600)MillerMirmoeeni, Seyyedmohammadsadeq (57218585171)Seyyedmohammadsadeq (57218585171)MirmoeeniMisganaw, Awoke (57202808713)Awoke (57202808713)MisganawMishra, Manish (57213025989)Manish (57213025989)MishraMisra, Sanjeev (35501005200)Sanjeev (35501005200)MisraMittal, Chaitanya (57200363487)Chaitanya (57200363487)MittalMohammadi, Esmaeil (57210443452)Esmaeil (57210443452)MohammadiMokdad, Ali H (7004813962)Ali H (7004813962)MokdadMoni, Mohammad Ali (35119094400)Mohammad Ali (35119094400)MoniMostafavi, Ebrahim (57440829200)Ebrahim (57440829200)MostafaviMubarik, Sumaira (57202290474)Sumaira (57202290474)MubarikMulita, Francesk (57200275021)Francesk (57200275021)MulitaMulualem, Jember Azanaw (58660537200)Jember Azanaw (58660537200)MulualemMulugeta, Temesgen (57219864186)Temesgen (57219864186)MulugetaMurray, Christopher J L (55481130700)Christopher J L (55481130700)MurrayMyers, Isabella (8845533900)Isabella (8845533900)MyersNayak, Biswa Prakash (56639942500)Biswa Prakash (56639942500)NayakNayak, Vinod C (24385399000)Vinod C (24385399000)NayakNejadghaderi, Seyed Aria (57218948511)Seyed Aria (57218948511)NejadghaderiNguyen, Huong Lan Thi (57226837406)Huong Lan Thi (57226837406)NguyenNguyen, Van Thanh (58491437100)Van Thanh (58491437100)NguyenNouraei, Hasti (55360408900)Hasti (55360408900)NouraeiNzoputam, Ogochukwu Janet (57819279400)Ogochukwu Janet (57819279400)NzoputamOkati-Aliabad, Hassan (57211186862)Hassan (57211186862)Okati-AliabadOlufadewa, Isaac Iyinoluwa (57216286071)Isaac Iyinoluwa (57216286071)OlufadewaOrdak, Michal (55992015900)Michal (55992015900)OrdakPadron-Monedero, Alicia (56532107100)Alicia (56532107100)Padron-MonederoPadubidri, Jagadish Rao (58295062300)Jagadish Rao (58295062300)PadubidriPandey, Ashok (57210886573)Ashok (57210886573)PandeyPant, Suman (57219171446)Suman (57219171446)PantParekh, Utsav (55804990900)Utsav (55804990900)ParekhPawar, Shrikant (58594958600)Shrikant (58594958600)PawarPeden, Amy E (32367835400)Amy E (32367835400)PedenPetcu, Ionela-Roxana (57094897500)Ionela-Roxana (57094897500)PetcuPiel, Frédéric B (56866735900)Frédéric B (56866735900)PielPiracha, Zahra Zahid (57189084862)Zahra Zahid (57189084862)PirachaPourali, Ghazaleh (57430263500)Ghazaleh (57430263500)PouraliQattea, Ibrahim (57222260346)Ibrahim (57222260346)QatteaQureshi, Maryam Faiz (58660713100)Maryam Faiz (58660713100)QureshiRaghav, Pankaja Raghav (57208123272)Pankaja Raghav (57208123272)RaghavRahman, Mosiur (55457953000)Mosiur (55457953000)RahmanRahmani, Shayan (57226290079)Shayan (57226290079)RahmaniRamasubramani, Premkumar (59722112000)Premkumar (59722112000)RamasubramaniRamazanu, Sheena (57211945291)Sheena (57211945291)RamazanuRawaf, Salman (6602475959)Salman (6602475959)RawafRezaei, Nazila (36700192900)Nazila (36700192900)RezaeiRezaei, Negar (57218820767)Negar (57218820767)RezaeiRezaeian, Mohsen (15053682700)Mohsen (15053682700)RezaeianSaddik, Basema (23020079300)Basema (23020079300)SaddikSadeghi, Malihe (57209615078)Malihe (57209615078)SadeghiSadeghian, Farideh (55538549800)Farideh (55538549800)SadeghianSaeed, Umar (36612315100)Umar (36612315100)SaeedSahebkar, Amirhossein (26639699900)Amirhossein (26639699900)SahebkarSaif, Zahra (6504795461)Zahra (6504795461)SaifSakshaug, Joseph W (35300521200)Joseph W (35300521200)SakshaugSalahi, Saina (58023701500)Saina (58023701500)SalahiSalamati, Payman (14045860600)Payman (14045860600)SalamatiSamy, Abdallah M (36973661300)Abdallah M (36973661300)SamySarmiento-Suárez, Rodrigo (57204744430)Rodrigo (57204744430)Sarmiento-SuárezSchwebel, David C (6603681532)David C (6603681532)SchwebelSenthilkumaran, Subramanian (36191387000)Subramanian (36191387000)SenthilkumaranSeylani, Allen (57222325334)Allen (57222325334)SeylaniShaikh, Masood Ali (57203122601)Masood Ali (57203122601)ShaikhSham, Sunder (58031551200)Sunder (58031551200)ShamShashamo, Bereket Beyene (57223025060)Bereket Beyene (57223025060)ShashamoSheikhi, Rahim Ali (39962437200)Rahim Ali (39962437200)SheikhiShetty, B Suresh Kumar (7102818010)B Suresh Kumar (7102818010)ShettyShetty, Pavanchand H (56366875300)Pavanchand H (56366875300)ShettySibhat, Migbar Mekonnen (57222351357)Migbar Mekonnen (57222351357)SibhatSingh, Harpreet (57215069784)Harpreet (57215069784)SinghSingh, Paramdeep (57202809996)Paramdeep (57202809996)SinghSisay, Eskinder Ayalew (57257093200)Eskinder Ayalew (57257093200)SisaySolomon, Yonatan (57220875005)Yonatan (57220875005)SolomonTaheri, Majid (57196608691)Majid (57196608691)TaheriUllah, Irfan (56992676600)Irfan (56992676600)UllahUllah, Sana (56402784100)Sana (56402784100)UllahViolante, Francesco S. (7003555890)Francesco S. (7003555890)ViolanteVu, Linh Gia (57210070319)Linh Gia (57210070319)VuWickramasinghe, Nuwan Darshana (55326938000)Nuwan Darshana (55326938000)WickramasingheYigit, Arzu (57820497600)Arzu (57820497600)YigitYonemoto, Naohiro (57204947657)Naohiro (57204947657)YonemotoYousefi, Zabihollah (9743306100)Zabihollah (9743306100)YousefiZaman, Muhammad (56397661100)Muhammad (56397661100)ZamanZastrozhin, Mikhail Sergeevich (56728932200)Mikhail Sergeevich (56728932200)ZastrozhinZhang, Zhi-Jiang (56068578400)Zhi-Jiang (56068578400)ZhangZheng, Peng (57213707656)Peng (57213707656)ZhengSteinmetz, Jaimie D. (57221591053)Jaimie D. (57221591053)SteinmetzVos, Theo (57223885848)Theo (57223885848)VosNaghavi, Mohsen (57207906323)Mohsen (57207906323)NaghaviOng, Kanyin Liane (57210793447)Kanyin Liane (57210793447)OngOng, Liane (58245634100)Liane (58245634100)OngZoladl, Mohammad (53980736300)Mohammad (53980736300)ZoladlChu, Dinh-Toi (56239816300)Dinh-Toi (56239816300)Chu2025-06-122025-06-122023https://doi.org/10.1016/S2468-2667(23)00185-8https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174744964&doi=10.1016%2fS2468-2667%2823%2900185-8&partnerID=40&md5=548b4d88dda9bb18c3a87a4db139ed2fhttps://remedy.med.bg.ac.rs/handle/123456789/2492Background: Unintentional carbon monoxide poisoning is a largely preventable cause of death that has received insufficient attention. We aimed to conduct a comprehensive global analysis of the demographic, temporal, and geographical patterns of fatal unintentional carbon monoxide poisoning from 2000 to 2021. Methods: As part of the latest Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), unintentional carbon monoxide poisoning mortality was quantified using the GBD cause of death ensemble modelling strategy. Vital registration data and covariates with an epidemiological link to unintentional carbon monoxide poisoning informed the estimates of death counts and mortality rates for all locations, sexes, ages, and years included in the GBD. Years of life lost (YLLs) were estimated by multiplying deaths by remaining standard life expectancy at age of death. Population attributable fractions (PAFs) for unintentional carbon monoxide poisoning deaths due to occupational injuries and high alcohol use were estimated. Findings: In 2021, the global mortality rate due to unintentional carbon monoxide poisoning was 0·366 per 100 000 (95% uncertainty interval 0·276–0·415), with 28 900 deaths (21 700–32 800) and 1·18 million YLLs (0·886–1·35) across all ages. Nearly 70% of deaths occurred in males (20 100 [15 800–24 000]), and the 50–54-year age group had the largest number of deaths (2210 [1660–2590]). The highest mortality rate was in those aged 85 years or older with 1·96 deaths (1·38–2·32) per 100 000. Eastern Europe had the highest age-standardised mortality rate at 2·12 deaths (1·98–2·30) per 100 000. Globally, there was a 53·5% (46·2–63·7) decrease in the age-standardised mortality rate from 2000 to 2021, although this decline was not uniform across regions. The overall PAFs for occupational injuries and high alcohol use were 13·6% (11·9–16·0) and 3·5% (1·4–6·2), respectively. Interpretation: Improvements in unintentional carbon monoxide poisoning mortality rates have been inconsistent across regions and over time since 2000. Given that unintentional carbon monoxide poisoning is almost entirely preventable, policy-level interventions that lower the risk of carbon monoxide poisoning events should be prioritised, such as those that increase access to improved heating and cooking devices, reduce carbon monoxide emissions from generators, and mandate use of carbon monoxide alarms. Funding: Bill & Melinda Gates Foundation. © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license