Artiko, Vera (55887737000)Vera (55887737000)ArtikoSobic-Saranovic, D. (57202567582)D. (57202567582)Sobic-SaranovicPavlovic, S. (57225355345)S. (57225355345)PavlovicPetrovic, M. (55989504900)M. (55989504900)PetrovicZuvela, M. (6602952252)M. (6602952252)ZuvelaAntic, A. (6603457520)A. (6603457520)AnticMatic, S. (7004660212)S. (7004660212)MaticOdalovic, S. (57218390032)S. (57218390032)OdalovicPetrovic, N. (7006674561)N. (7006674561)PetrovicMilovanovic, A. (57213394853)A. (57213394853)MilovanovicObradovic, V. (7003389726)V. (7003389726)Obradovic2025-07-022025-07-022012https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867544830&partnerID=40&md5=4a323cd1cad2e0e091cca0c4368203c6https://remedy.med.bg.ac.rs/handle/123456789/14052Purpose: To assess the value of whole body scintigraphy using 99mTc-HYNIC-TOC (Tektrotyd) and with single photon emission computerized tomography (SPECT) in the detection of primary and metastatic neuroendocrine tumors (NETs). Methods: Thirty patients with different neuroendocrine tumors, mainly gastroenteropancreatic (GEP), were investigated. Whole body scintigraphy was performed 2 h (if necessary 10 min and 24 h) after i.v. administration of 740 Mbq 99mTc-Tektrotyd, Polatom. In cases of unclear findings obtained by whole body scintigraphy, investigation was followed by SPECT. Results: From 12 patients with NETs of unknown origin, there were 10 true positive (TP), and 2 false negative (FN) findings. Diagnosis was made with SPECT in 6 patients. From 8 patients with gut carcinoids, there were 4 TP, 2 true negative (TN), one FN, and one false positive (FP) finding. Diagnosis was made with SPECT in 2 patients. From 7 patients with neuroendocrine pancreatic carcinomas there were 4 TP and 3 TN findings. Diagnosis was made with SPECT in 2 patients. From 3 patients with gastrinomas there were 2 TP findings and one TN findings. Diagnosis was made with SPECT findings in 2 patients. Sensitivity of 99mTc-HYNIC-TOC was 87%, specificity 86%, positive predictive value 95%, negative predictive value 67% and accuracy 87%. Conclusion: We concluded that scintigraphy with 99mTc-Tektrotyd is an useful method for diagnosis, staging and follow up of the patients with NETs. © 2012 Zerbinis Medical Publications.^99mTc-HYNIC-TOCNeuroendocrine tumorsRadionuclide imaging