Milan, Zoka (41262306300)Zoka (41262306300)MilanKatyayani, Katyayani (57205250476)Katyayani (57205250476)KatyayaniCubas, Georgina (56373351600)Georgina (56373351600)CubasUnic-Stojanovic, Dragana (55376745500)Dragana (55376745500)Unic-StojanovicCooper, Mariese (57208838745)Mariese (57208838745)CooperBras, Paul (57205461216)Paul (57205461216)BrasMacmillan, Joseph (57208836036)Joseph (57208836036)Macmillan2025-06-122025-06-122019https://doi.org/10.1111/vox.12771https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065904036&doi=10.1111%2fvox.12771&partnerID=40&md5=e16b76a61a0a5f87d28a750bee6afe8ehttps://remedy.med.bg.ac.rs/handle/123456789/5636Background: We investigated changes to transfusion practices over time in paediatric liver transplant centre and evaluated the effect of transfusion practice to mortality. Methods: A pilot retrospective study included two cohorts each with 101 sequential paediatric LT recipients: an Early group (1994–1998) and a Recent group (2009–2013). Demographic characteristics and data on the intraoperative transfusion of red blood cells (RBC), fresh-frozen plasma (FFP), platelets and cryoprecipitate were collected. Postoperative laboratory results were also obtained, together with donor and data regarding 1- and 5-year survival. Appropriate intergroup comparisons, univariate and multivariate analysis were made and P ≤ 0·05 was considered statistically significant. Results: There were no significant group differences in demographic data (except patient height). Despite the fact that median total blood loss did not differ between groups (111 ml/kg in both groups), the Early group had greater levels of intraoperative RBC transfusion (75 vs. 59 ml/kg, respectively, P = 0·04) and less use of FFP (53 vs. 62 ml/kg, respectively, P = 0·01). Overall we noted a lower 1- and 5-year survival in the Early group (88·2% vs. 96%, P = 0·04 and 82·4% vs. 89·1%, P = 0·01, respectively). Univariate, but not multivariate regression analyses demonstrated that higher PELD score, RBC and FFP transfusion, and inclusion in the Early group were contributing factors to 1-year higher mortality. Conclusions: This retrospective analysis of blood loss and replacement in paediatric LT patients demonstrates that the majority of our patients suffer major haemorrhage and require large-volume RBC and FFP replacements. In our pilot study, large volume of RBC and FFP replacement did not contribute to mortality. Paediatric LT involves a number of multidisciplinary teams. Thus, all care-related factors and combinations thereof that may contribute to outcome and should be evaluated in the future. © 2019 International Society of Blood Transfusionblood transfusionliver transplantationpaediatric