Drulović, Jelena (55886929900)Jelena (55886929900)DrulovićMostarica-Stojković, Marija (6701741422)Marija (6701741422)Mostarica-StojkovićLević, Zvonimir (7003341242)Zvonimir (7003341242)LevićStojsavljević, Nebojša (6603086728)Nebojša (6603086728)StojsavljevićPravica, Vera (7003322504)Vera (7003322504)PravicaMesaroš, Šarlota (7004307592)Šarlota (7004307592)Mesaroš2025-07-022025-07-021997https://doi.org/10.1016/S0022-510X(96)05320-8https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031569803&doi=10.1016%2fS0022-510X%2896%2905320-8&partnerID=40&md5=03edae0cfd748f485c1c5503f7cb532fhttps://remedy.med.bg.ac.rs/handle/123456789/14586Concentrations of interleukin (IL)-12 and tumor necrosis factor-α (TNF-α) in cerebrospinal fluid (CSF) were measured in patients with multiple sclerosis (MS) and control patients with non-inflammatory neurological diseases (NIND) by an enzyme-linked immunosorbent assay. TNF-α was detectable in the CSF of 60% of the patients with active MS, none of those with inactive MS and 29% of patients with NIND. CSF concentrations of TNF-α correlated with the degree of disability in MS patients (P<0.05). Detectable levels of IL-12 were found in 10% of the MS CSF samples and 18% of NIND CSF samples. There was a significant relationship between CSF concentrations of IL-12 and those of TNF-α in MS patients (P<0.05); no relationship was observed between the presence of IL-12 and disease activity or severity. These findings further stress the involvement of T helper 1 type-response within the central nervous system in MS.Cerebrospinal fluidInterleukin-12Multiple sclerosisTumor necrosis factor-α