Vlajinac, Hristina (7006581450)Hristina (7006581450)VlajinacŠipetić, Sandra (6701802171)Sandra (6701802171)ŠipetićMarinković, Jelena (7004611210)Jelena (7004611210)MarinkovićBjekić, Milan (6602745387)Milan (6602745387)BjekićKocev, Nikola (6602672952)Nikola (6602672952)KocevSajić, Silvija (24073590000)Silvija (24073590000)Sajić2025-06-132025-06-132006https://doi.org/10.1111/j.1365-3016.2006.00713.xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33645756823&doi=10.1111%2fj.1365-3016.2006.00713.x&partnerID=40&md5=f0974d0ccc1764524a14a11ff9799200https://remedy.med.bg.ac.rs/handle/123456789/11032A case-control study was conducted in Belgrade (about 320 000 inhabitants 0-16 years old) during the period 1994-97, comprising 68 diabetic children (cases) and 68 controls chosen from the siblings of the cases. Analysis using multivariable logistic regression analysis indicated the following independent risk factors for Type 1 diabetes: higher birth order, infections during the 6 months preceding the onset of the disease and stressful events. Out of individual stressful and psychological factors, 'other' stressful events (severe accident or hospitalisation or death of a close friend, conflict with a teacher, death of a pet, failure in competition, quarrel between parents, punishment, physical attack, war in republics of former Yugoslavia and near drowning in the pool) and learning problems were independent risk factor for Type 1 diabetes. The results obtained in this study of siblings supports the hypothesis that environmental factors play a role in the development of Type 1 diabetes. ©2006 Blackwell Publishing Ltd.InfectionLearning problemsSiblingsStressful life eventsType 1 diabetes mellitus