Kovač, Jelena Djokić (52563972900)Jelena Djokić (52563972900)KovačJešić, Rada (6701488512)Rada (6701488512)JešićStanisavljević, Dejana (23566969700)Dejana (23566969700)StanisavljevićKovač, Bojan (52563978600)Bojan (52563978600)KovačBanko, Bojan (35809871900)Bojan (35809871900)BankoSeferović, Petar (6603594879)Petar (6603594879)SeferovićMaksimović, Ružica (55921156500)Ružica (55921156500)Maksimović2025-06-122025-06-122012https://doi.org/10.1007/s00330-011-2296-yhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84856618158&doi=10.1007%2fs00330-011-2296-y&partnerID=40&md5=14e9fcaff103f056c26e25fa18dcc777https://remedy.med.bg.ac.rs/handle/123456789/9717Objectives: To evaluate magnetic resonance imaging (MRI) findings in patients with primary biliary cirrhosis (PBC) and to determine the value of diffusion-weighted imaging (DWI) in the assessment of liver fibrosis. Materials and methods: The following MRI findings were reviewed in 44 patients: periportal T2-weighted hyperintensity, periportal halo sign (T1- and T2-weighted periportal hypointensity), lymphadenopathy, signs of portal hypertension and morphological liver changes. Apparent diffusion coefficient (ADC) was calculated for six locations in the liver for b = 800 s/mm 2. Results: Periportal hyperintensity and periportal halo sign were observed in 72.7% and 66.7% of patients, respectively. Lymphadenopathy was noted in 28 patients (63.6%) and diffuse hepatomegaly in 18 (40.9%). Significant positive correlation was observed between histological stage and periportal halo sign (p = 0.613), hepatomegaly (p = 0.443), and portosystemic collaterals (p = 0.391). The mean ADCs (×10 -3 mm 2/s) were significantly different at stage I versus III and IV, and stage II versus IV. No significant difference was found between stages II and III. For prediction of stage ≥ II and stage ≥ III areas under receiver operating characteristic curves were 0.879 and 0.906, respectively. Conclusion: MRI with DWI could be used as a part of diagnostic protocol in the further evaluation of PBC patients providing noninvasive assessment of liver fibrosis progression. Key Points : • MRI provides insight into the morphological liver changes in primary biliary cirrhosis (PBC) • The periportal "halo" sign is a highly specific finding in PBC • Diffusion-weighted MR imaging allows noninvasive assessment of liver fibrosis grade © 2011 European Society of Radiology.Diffusion-weighted imagingLiverLiver fibrosisMagnetic resonance imagingPrimary biliary cirrhosis