Arsenijevic, Tatjana (6508074168)Tatjana (6508074168)ArsenijevicNikitovic, Marina (6602665617)Marina (6602665617)NikitovicPlesinac-Karapandzic, Vesna (23474669800)Vesna (23474669800)Plesinac-KarapandzicStojanovic-Rundic, Suzana (23037160700)Suzana (23037160700)Stojanovic-RundicGavrilovic, Dusica (8849698200)Dusica (8849698200)GavrilovicMicev, Marjan (7003864533)Marjan (7003864533)MicevPesko, Predrag (7004246956)Predrag (7004246956)Pesko2025-07-022025-07-022017https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045552093&partnerID=40&md5=df4f717656da0a40ada21acd9018c878https://remedy.med.bg.ac.rs/handle/123456789/13143Purpose: To analyse the overall survival (OS) of patients with locally advanced, unresectable esophageal cancer treated with chemoradiation (CRT) with or without surgery. Methods: CRT was administered to 63 patients with locally advanced (T3-4, N0-1), initially unresectable squamous cell esophageal cancer. After the assessment of tumor response to treatment, medically fit patients converted to operable stage were subjected to surgery. Regular follow-up was performed every 3 months during first 2 years, and then every 6 months. Results: All 63 patients completed the whole radiotherapy course. Forty patients (63%) received complete 4 cycles of chemotherapy. In the remaining 23 patients (37%) chemotherapy was interrupted due to toxicity. Clinical response to CRT was: complete response (CR) in 4 patients (6%), partial response (PR) in 27 (43%), stable disease (SD) in 22 (35%) patients, and 10 patients (16%) had disease progression (PD). After reevaluation, 23 patients (15 PR and 8 SD after CRT) underwent surgery (37%), all with R0 resection. OS in the whole group was 53% at one year, and 36% at two years. OS was significantly better in the operated group of patients than in the non-operated group. No statistically significant difference in OS was observed comparing operated to CR patients with no surgery (70 vs 50%). In the non-operated group of patients there was no difference in OS between CR, PR, and SD patients. Conclusions: With appropriate selection, patients with advanced squamous cell esophageal cancer should be considered for potentially effective treatment. © 2017 Zerbinis Publications. All rights reserved.ChemoradiationEsophageal cancerSurgerySurvival