Cvetinovic, Natasa (55340266600)Natasa (55340266600)CvetinovicSekularac, Nikola (23981224200)Nikola (23981224200)SekularacHaehling, Stephan Von (6602981479)Stephan Von (6602981479)HaehlingTahirovic, Elvis (24339336300)Elvis (24339336300)TahirovicInkrot, Simona (35784615000)Simona (35784615000)InkrotLainscak, Mitja (9739432000)Mitja (9739432000)LainscakApostolovic, Svetlana (13610076800)Svetlana (13610076800)ApostolovicPutnikovic, Biljana (6602601858)Biljana (6602601858)PutnikovicWaagstein, Finn (56216780700)Finn (56216780700)WaagsteinGelbrich, Goetz (14119833600)Goetz (14119833600)GelbrichAleksic, Andja (57206730766)Andja (57206730766)AleksicLoncar, Goran (55427750700)Goran (55427750700)LoncarDüngen, Hans-Dirk (16024171900)Hans-Dirk (16024171900)Düngen2025-07-022025-07-022018https://doi.org/10.2217/bmm-2018-0136https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061910845&doi=10.2217%2fbmm-2018-0136&partnerID=40&md5=bcdda3105b23ef21634afba107ba2095https://remedy.med.bg.ac.rs/handle/123456789/13102Aim: We investigated if the baseline value of mid-regional pro-atrial natriuretic peptide (NP), N-terminal pro-B-type NP and copeptin may be helpful in optimizing β-blocker uptitration in elderly patients with heart failure. Patients & methods: According to the biomarkers’ levels, 457 patients were divided into three subgroups and compared with each other at baseline and 3 months after. Results: All mid-regional pro-atrial NP and N-terminal pro-B-type NP subgroups had significant amelioration of left ventricle ejection fraction and New York Heart Association (NYHA) class after 3 months of β-blocker uptitration (p < 0.001). More prominent improvement of left ventricle ejection fraction and New York Heart Association class was observed in subgroups with lower versus higher NPs levels. Conclusion: NPs levels, unlike copeptin levels, might be useful tool for objective selection of elderly heart failure patients who could have the greatest benefit of forced uptitration. C 2018 Future Medicine LtdChronic heart failureCopeptinMid-regional pro-atrial natriuretic peptideN-terminal pro B-type natriuretic peptideΒ-blocker uptitration