Prognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?

Djordjevic, Dragan (7006039370)Dragan (7006039370)DjordjevicPejovic, Janko (16319628200)Janko (16319628200)PejovicSurbatovic, Maja (9232887700)Maja (9232887700)SurbatovicJevdjic, Jasna (25121306300)Jasna (25121306300)JevdjicRadakovic, Sonja (9232887900)Sonja (9232887900)RadakovicVeljovic, Milic (7801561212)Milic (7801561212)VeljovicPeric, Aneta (24825091000)Aneta (24825091000)PericAndjelic, Tamara (56437686400)Tamara (56437686400)AndjelicPopovic, Nada (35462343700)Nada (35462343700)Popovic2025-06-122025-06-122015https://doi.org/10.1515/jomb-2015-0002https://www.scopus.com/inward/record.uri?eid=2-s2.0-84942880955&doi=10.1515%2fjomb-2015-0002&partnerID=40&md5=e910da7b285bce16ed949cf1ac27046chttps://remedy.med.bg.ac.rs/handle/123456789/8087Background: Severe sepsis and/or trauma complicated by multiple organ dysfunction syndrome are the leading causes of death in critically ill patients. The aim of this prospective single-centre study was to assess the prognostic value and daily trend of interleukin-6 (IL-6), neutrophil CD64 expression, C-reactive protein (CRP) and lipopolysaccharide-binding protein (LBP) regarding outcome in critically ill patients with severe trauma and/or severe sepsis. Outcome measure was hospital mortality. Methods: One hundred and two critically ill patients admitted to the intensive care unit of a tertiary university hospital were enrolled in this prospective study. Blood samples were collected on admission (day 1), days 2 and 3. Results: CD64 index was 1.6-fold higher on day 1 and 1.78-fold higher on day 2 in non-survivors (p<0.05). The area under the curve (AUC) for the CD64 index on day 1 for outcome was 0.727. At a cut-off level of 2.80 sensitivity was 75% and specificity was 65%. Patients with CD64 index level on day 1 higher than 2.80 had 2.4-fold higher probability of dying. Odds ratio is 2.40; 95% CI 0.60-9.67. Conclusions: CD64 index on day 1 is a fairly good predictor of outcome. AUCs for IL-6, CRP and LBP were < 0.55, suggesting these biomarkers failed to predict outcome.biomarkerscritical careleukocytesoutcomeprognosisPrognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?