IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis

Malhotra, S. (50262475300)S. (50262475300)MalhotraMorcillo-Suárez, C. (24465436500)C. (24465436500)Morcillo-SuárezBrassat, D. (55666405000)D. (55666405000)BrassatGoertsches, R. (55882530700)R. (55882530700)GoertschesLechner-Scott, J. (6603311349)J. (6603311349)Lechner-ScottUrcelay, E. (10639601200)E. (10639601200)UrcelayFernández, O. (7102560044)O. (7102560044)FernándezDrulovic, J. (55886929900)J. (55886929900)DrulovicGarcía-Merino, A. (6602178754)A. (6602178754)García-MerinoMartinelli Boneschi, F. (57202042750)F. (57202042750)Martinelli BoneschiChan, A. (7403168324)A. (7403168324)ChanVandenbroeck, K. (7003943780)K. (7003943780)VandenbroeckNavarro, A. (35477108400)A. (35477108400)NavarroBustamante, M.F. (36647223700)M.F. (36647223700)BustamanteRío, J. (7006734684)J. (7006734684)RíoAkkad, D.A. (12787505100)D.A. (12787505100)AkkadGiacalone, G. (37037407500)G. (37037407500)GiacaloneSánchez, A.J. (37665880200)A.J. (37665880200)SánchezLeyva, L. (6602303467)L. (6602303467)LeyvaAlvarez-Lafuente, R. (13411081600)R. (13411081600)Alvarez-LafuenteZettl, U.K. (7004582854)U.K. (7004582854)ZettlOksenberg, J. (7005749242)J. (7005749242)OksenbergMontalban, X. (7007177960)X. (7007177960)MontalbanComabella, M. (6701491362)M. (6701491362)Comabella2025-06-122025-06-122011https://doi.org/10.1016/j.jneuroim.2011.08.004https://www.scopus.com/inward/record.uri?eid=2-s2.0-80054889075&doi=10.1016%2fj.jneuroim.2011.08.004&partnerID=40&md5=5959276bc93234a90da4b456120d0feahttps://remedy.med.bg.ac.rs/handle/123456789/9894Recent studies have revealed an association between interleukin 28B (IL28B) and response to IFN-alpha treatment in hepatitis C patients. Here we investigated the influence of IL28B polymorphisms in the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. We genotyped two SNPs of the IL28B gene (rs8099917 and rs12979860) in 588 MS patients classified into responders (n = 281) and non-responders (n = 307) to IFNβ. Combined analysis of the study cohorts showed no significant associations between SNPs rs8099917 and rs12979860 and the response to treatment. These findings do not support a role of IL28B polymorphisms in the response to IFNβ in MS patients. © 2011 Elsevier B.V.Interferon-betaMultiple sclerosisPolymorphismsResponseIL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis