Sobic-Saranovic, Dragana P. (57202567582)Dragana P. (57202567582)Sobic-SaranovicPavlovic, Smiljana V. (57225355345)Smiljana V. (57225355345)PavlovicArtiko, Vera M. (55887737000)Vera M. (55887737000)ArtikoSaranovic, Djordjije Z. (57190117313)Djordjije Z. (57190117313)SaranovicJaksic, Emilija D. (6507797044)Emilija D. (6507797044)JaksicSubotic, Dragan (6603099376)Dragan (6603099376)SuboticNagorni-Obradovic, Ljudmila (57189629141)Ljudmila (57189629141)Nagorni-ObradovicKozarevic, Nebojsa (6507691500)Nebojsa (6507691500)KozarevicPetrovic, Nebojsa (7006674561)Nebojsa (7006674561)PetrovicGrozdic, Isidora T. (37107616900)Isidora T. (37107616900)GrozdicObradovic, Vladimir B. (7003389726)Vladimir B. (7003389726)Obradovic2025-06-122025-06-122012https://doi.org/10.1097/RLU.0b013e3182335edbhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84856414986&doi=10.1097%2fRLU.0b013e3182335edb&partnerID=40&md5=2e96632b0f8059b38e229b57ecc3aab1https://remedy.med.bg.ac.rs/handle/123456789/9802Purpose: The aim of our study was to assess diagnostic accuracy of Tc-99m depreotide and Tc-99m-EDDA/HYNIC-TOC scintigraphy for evaluation of pulmonary lesions that appeared ambiguous on computed tomography (CT). Material and Methods: Forty-nine consecutive patients (37 men and 12 women; mean age, 60 ± 11 years) with 60 pulmonary lesions on chest radiography and CT were referred for nuclear imaging. They were prospectively allocated to undergo whole-body scintigraphy (WBS) and single photon emission computed tomography (SPECT) using either Tc-99m depreotide (26 patients, group 1) or Tc-99m-EDDA/HYNIC-TOC imaging (23 patients, group 2). Histologic findings after tissue biopsy served as a gold standard for determining diagnostic accuracy of the 2 somatostatin analogs. Visual assessment was complemented by semiquantitative analysis based on target to background ratio. Results: Among the 32 pulmonary lesions scanned with Tc-99m depreotide, focal uptake was increased in 22 of 25 malignancies, whereas no uptake was found in 6 of 7 benign lesions (88% sensitivity, 85% specificity, and 88% accuracy) on both WBS and SPECT. Imaging of 28 pulmonary lesions with Tc-99m-EDDA/HYNIC-TOC had a similar diagnostic yield (sensitivity 87%, specificity 84%, and accuracy 86%). Overall, target to background ratios were higher on SPECT than WBS but not significantly different between groups 1 and 2 (SPECT 2.72 ± 0.70 vs. 2.71 ± 0.50, WBS 1.61 ± 0.32 vs. 1.62 ± 0.28, respectively). Conclusion: This study demonstrates that Tc-99m depreotide and Tc-99m-EDDA/HYNIC-TOC have similar diagnostic value for characterizing pulmonary lesions that appear ambiguous on CT. Copyright © 2012 by Lippincott Williams & Wilkins.Pulmonary lesionSpectTc-99m depreotideTc-99m-EDDA/HYNIC-TOC