Kolaković, Ana (36343835300)Ana (36343835300)KolakovićŽvković, Maja (8699858500)Maja (8699858500)ŽvkovićRadak, Djordje (7004442548)Djordje (7004442548)RadakDjurić, Tamara (9734588600)Tamara (9734588600)DjurićKončar, Igor (19337386500)Igor (19337386500)KončarDavidović, Lazar (7006821504)Lazar (7006821504)DavidovićDinčić, Dragan (6603052715)Dragan (6603052715)DinčićAlavantić, Dragan (6604046863)Dragan (6604046863)AlavantićStanković, Aleksandra (7006485474)Aleksandra (7006485474)Stanković2025-06-122025-06-122012https://doi.org/10.1177/1470320311423271https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859969050&doi=10.1177%2f1470320311423271&partnerID=40&md5=54777f063e0a23d5353e74de04f0784ehttps://remedy.med.bg.ac.rs/handle/123456789/9751Introduction: The ACE I/D polymorphism was mostly investigated in association with intima-media thickness, rarely with severe atherosclerotic phenotype.Materials and methods: We investigated the association of I/D polymorphism with severe carotid atherosclerosis (CA) (stenosis > 70%) in asymptomatic and symptomatic patients undergoing carotid endarterectomy. The 504 patients subjected to endarterectomy and 492 healthy controls from a population in Serbia were investigated as a case-control study.Results: The univariate logistic regression analysis revealed ACE DD as a significant risk factor for severe CA (odds ratio [OR] = 1.3, 95% confidence interval [CI] 1.0-1.7, p = 0.04). After adjustment for the common risk factors (age, hypertension, smoking, and HDL) ACE was no longer significant. However, we found a significant independent influence of DD genotype on plaque presence in a normotensive subgroup of patients (OR 1.8, CI 1.2-3.0, p = 0.01, corrected for multiple testing). In symptomatic patients D allele carriers were significantly more frequent compared with asymptomatic patients (OR 1.6 CI 1.0-2.6, p = 0.05).Conclusions: Our data suggests that ACE I/D is not an independent risk factor for severe CA. On the other hand, a significant independent genetic influence of ACE I/D appeared in normotensive and symptomatic patients with severe CA. This should be considered in further research toward resolving the complex genetic background of severe CA phenotype. © The Author(s) 2011.ACE I/Dcarotid plaqueendarterectomygenepolymorphism