Mitrovic, B. (57211280115)B. (57211280115)MitrovicGluvic, Z. (24460256500)Z. (24460256500)GluvicKlisic, A. (56160473800)A. (56160473800)KlisicObradovic, Milan (48061421600)Milan (48061421600)ObradovicMacut, D. (35557111400)D. (35557111400)MacutTomasevic, R. (6603547250)R. (6603547250)TomasevicIsenovic, E.R. (14040488600)E.R. (14040488600)Isenovic2025-06-122025-06-122022https://doi.org/10.4183/aeb.2022.480https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159816690&doi=10.4183%2faeb.2022.480&partnerID=40&md5=fb86678d60696269fd1a3044a5af2613https://remedy.med.bg.ac.rs/handle/123456789/3321Context. Prognostic considerations include assessing the risk of liver fibrosis in people with non-alcoholic fatty liver disease (NAFLD). Objectives. This study evaluates the use of hematologic and metabolic parameters regarding liver steatosis and fibrosis scores (FLI and Fib-4) in non-obese type 2 diabetes mellitus (t2DM) patients with NAFLD. Methods. Subjects underwent abdominal ultrasound examinations, and FLI and Fib-4 scores were calculated to evaluate liver steatosis and the risk of liver fibrosis non-invasively: 61 non-obese NAFLD subjects with t2DM were included in the cohort study and were divided into 2 groups depending on the t2DM treatment regimen. Results. Fib-4 and WBC count demonstrated a significant inverse correlation (OR = 0.509, p = 0.007). WBC count had an R2 of 0.237, indicating that this marker could account for up to 23.7% of a variation in Fib-4. Fib-4 and FFA had positive correlation which did not achieve statistically significant prediction (OR=7.122, p=0.062). Additionally, a significant prediction of HbA1c (OR=1.536, p=0.016) and haemoglobin (OR=1.071, p=0.020) for FLI was revealed. Conclusion. HbA1c and other haematological and metabolic parameters, such as haemoglobin and WBC, may be another non-invasive tool for determining whether non-obese NAFLD patients with t2DM are at risk of developing liver steatosis and fibrosis. © 2022, Acta Endocrinologica Foundation. All rights reserved.Fib-4FLI scoreliver biopsyliver fibrosisNAFLDt2DM