Biljic-Erski, Aleksandar (57210440392)Aleksandar (57210440392)Biljic-ErskiRajovic, Nina (57218484684)Nina (57218484684)RajovicPavlovic, Vedrana (57202093978)Vedrana (57202093978)PavlovicBukumiric, Zoran (36600111200)Zoran (36600111200)BukumiricRakic, Aleksandar (57217053634)Aleksandar (57217053634)RakicRovcanin, Marija (57219309601)Marija (57219309601)RovcaninStulic, Jelena (57209247701)Jelena (57209247701)StulicAnicic, Radomir (55566374100)Radomir (55566374100)AnicicKocic, Jovana (57192953792)Jovana (57192953792)KocicCumic, Jelena (57209718077)Jelena (57209718077)CumicMarkovic, Ksenija (57252972500)Ksenija (57252972500)MarkovicZdravkovic, Dimitrije (59330041800)Dimitrije (59330041800)ZdravkovicStanisavljevic, Dejana (23566969700)Dejana (23566969700)StanisavljevicMasic, Srdjan (57190441485)Srdjan (57190441485)MasicMilic, Natasa (7003460927)Natasa (7003460927)MilicDimitrijevic, Dejan (57222992204)Dejan (57222992204)Dimitrijevic2025-06-122025-06-122025https://doi.org/10.3390/jcm14051721https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000631410&doi=10.3390%2fjcm14051721&partnerID=40&md5=215492f4ccd26a6905a21622fa4c49edhttps://remedy.med.bg.ac.rs/handle/123456789/501Background: The purpose of this meta-analysis was to examine the prevalence of hypertensive disorders of pregnancy (HDPs), particularly preeclampsia (PE), in peripartum cardiomyopathy (PPCM)-affected pregnancies, and to evaluate whether a HDP significantly alters the prognosis of PPCM, with specific reference to the recovery of left ventricular function (LVEF) and mortality. Methods: A total of 5468 potentially eligible studies were identified, and 104 were included in the meta-analysis. For pooling proportions, the inverse variance methods with logit transformation were used. Complete recovery of LVEF (>50%) and mortality were expressed by odds ratios (ORs), with 95% confidence intervals (CIs). The Peto OR (POR) was used in cases of rare events. Baseline LV function and baseline LV end-diastolic diameter (LVEDD) were summarized by the mean difference (MD) and 95% confidence interval (CI). Results: The summary estimate of the prevalence of HDPs and PE in women with PPCM was 36% and 25%, respectively. Patients with HDPs and, more specifically, PE with PPCM had a higher chance of complete recovery (OR = 1.87; 95%CI = 1.64 to 2.13; p < 0.001 and OR = 1.98; 95%CI 1.69 to 2.32; p < 0.001, respectively), a higher baseline LVEF (MD, 1.42; 95% CI 0.16 to 2.67; p = 0.03 and MD, 1.69; 95% CI 0.21 to 3.18; p = 0.03, respectively), and a smaller baseline LVEDD (MD, −1.31; 95% CI −2.50 to −0.13; p = 0.03 and MD, −2.63; 95% CI −3.75 to −1.51; p < 0.001, respectively). These results, however, did not translate into a significant difference in 12-month mortality (POR = 0.80; 95% CI = 0.57 to 1.13; p = 0.21 and POR = 1.56; 95% CI 0.90 to 2.73; p = 0.12, respectively). Conclusions: The findings of this study may contribute to evidence that can be utilized to aid in the risk stratification of patients with PPCM regarding their long-term prognoses. © 2025 by the authors.hypertensive disordermeta-analysisperipartum cardiomyopathypreeclampsiapregnancy