Sartelli, Massimo (6506102337)Massimo (6506102337)SartelliKluger, Yoram (55360783700)Yoram (55360783700)KlugerAnsaloni, Luca (58203015800)Luca (58203015800)AnsaloniHardcastle, Timothy C. (22634561500)Timothy C. (22634561500)HardcastleRello, Jordi (7102682070)Jordi (7102682070)RelloWatkins, Richard R. (24175443500)Richard R. (24175443500)WatkinsBassetti, Matteo (58763953600)Matteo (58763953600)BassettiGiamarellou, Eleni (15743985400)Eleni (15743985400)GiamarellouCoccolini, Federico (24478295400)Federico (24478295400)CoccoliniAbu-Zidan, Fikri M. (12786811900)Fikri M. (12786811900)Abu-ZidanAdesunkanmi, Abdulrashid K. (7003654302)Abdulrashid K. (7003654302)AdesunkanmiAugustin, Goran (22955694500)Goran (22955694500)AugustinBaiocchi, Gian L. (54379670700)Gian L. (54379670700)BaiocchiBala, Miklosh (14049825800)Miklosh (14049825800)BalaBaraket, Oussema (36089674400)Oussema (36089674400)BaraketBeltran, Marcelo A. (8374624600)Marcelo A. (8374624600)BeltranJusoh, Asri Che (54399788200)Asri Che (54399788200)JusohDemetrashvili, Zaza (12774275000)Zaza (12774275000)DemetrashviliDe Simone, Belinda (35603299300)Belinda (35603299300)De Simonede Souza, Hamilton P. (56265647200)Hamilton P. (56265647200)de SouzaCui, Yunfeng (36016343600)Yunfeng (36016343600)CuiDavies, R.Justin (58973186000)R.Justin (58973186000)DaviesDhingra, Sameer (57363710300)Sameer (57363710300)DhingraDiaz, Jose J. (56691867600)Jose J. (56691867600)DiazDi Saverio, Salomone (12777436800)Salomone (12777436800)Di SaverioDogjani, Agron (43161018900)Agron (43161018900)DogjaniElmangory, Mutasim M. (55775124800)Mutasim M. (55775124800)ElmangoryEnani, Mushira A. (6506595796)Mushira A. (6506595796)EnaniFerrada, Paula (12776024800)Paula (12776024800)FerradaFraga, Gustavo P. (16416659200)Gustavo P. (16416659200)FragaFrattima, Sabrina (36548069500)Sabrina (36548069500)FrattimaGhnnam, Wagih (24329004400)Wagih (24329004400)GhnnamGomes, Carlos A. (15764934000)Carlos A. (15764934000)GomesKanj, Souha S. (7003794354)Souha S. (7003794354)KanjKaramarkovic, Aleksandar (6507164080)Aleksandar (6507164080)KaramarkovicKenig, Jakub (14622658100)Jakub (14622658100)KenigKhamis, Faryal (55218145400)Faryal (55218145400)KhamisKhokha, Vladimir (55221789900)Vladimir (55221789900)KhokhaKoike, Kaoru (35411493100)Kaoru (35411493100)KoikeKok, Kenneth Y.Y. (7006862619)Kenneth Y.Y. (7006862619)KokIsik, Arda (57159146500)Arda (57159146500)IsikLabricciosa, Francesco M. (56576409100)Francesco M. (56576409100)LabricciosaLatifi, Rifat (6602717836)Rifat (6602717836)LatifiLee, Jae G. (35187320300)Jae G. (35187320300)LeeLitvin, Andrey (57207954940)Andrey (57207954940)LitvinMachain, Gustavo M. (57190389630)Gustavo M. (57190389630)MachainManzano-Nunez, Ramiro (57189025202)Ramiro (57189025202)Manzano-NunezMajor, Piotr (35424044300)Piotr (35424044300)MajorMarwah, Sanjay (7006074895)Sanjay (7006074895)MarwahMcFarlane, Michael (35580706800)Michael (35580706800)McFarlaneMemish, Ziad A. (7005059350)Ziad A. (7005059350)MemishMesina, Cristian (14719655100)Cristian (14719655100)MesinaMoore, Ernest E. (35351716300)Ernest E. (35351716300)MooreMoore, Frederick A. (35372847200)Frederick A. (35372847200)MooreNaidoo, Noel (54908375000)Noel (54908375000)NaidooNegoi, Ionut (57200640014)Ionut (57200640014)NegoiOfori-Asenso, Richard (57209300265)Richard (57209300265)Ofori-AsensoOlaoye, Iyiade (12769098700)Iyiade (12769098700)OlaoyeOrdoñez, Carlos A. (22945136700)Carlos A. (22945136700)OrdoñezOuadii, Mouaqit (36114877900)Mouaqit (36114877900)OuadiiPaolillo, Ciro (57195035714)Ciro (57195035714)PaolilloPicetti, Edoardo (6507271125)Edoardo (6507271125)PicettiPintar, Tadeja (23393780800)Tadeja (23393780800)PintarPonce-de-Leon, Alfredo (7003924320)Alfredo (7003924320)Ponce-de-LeonPupelis, Guntars (56008134900)Guntars (56008134900)PupelisReis, Tarcisio (57194160160)Tarcisio (57194160160)ReisSakakushev, Boris (56156191300)Boris (56156191300)SakakushevKafil, Hossein Samadi (16233382900)Hossein Samadi (16233382900)KafilSato, Norio (56156095800)Norio (56156095800)SatoShah, Jay N. (18233816400)Jay N. (18233816400)ShahSiribumrungwong, Boonying (37017423200)Boonying (37017423200)SiribumrungwongTalving, Peep (18736541500)Peep (18736541500)TalvingTranà, Cristian (36452516400)Cristian (36452516400)TranàUlrych, Jan (25622846800)Jan (25622846800)UlrychYuan, Kuo-Ching (25931899300)Kuo-Ching (25931899300)YuanCatena, Fausto (6603701993)Fausto (6603701993)Catena2025-06-122025-06-122018https://doi.org/10.1186/s13017-018-0165-6https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041557584&doi=10.1186%2fs13017-018-0165-6&partnerID=40&md5=dc3c4fce0f0bbdd1b612e4276de5e9d6https://remedy.med.bg.ac.rs/handle/123456789/6518The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in the evolution of our understanding of sepsis. Nevertheless, more than a year after their publication, we have a few concerns regarding the use of the Sepsis-3 definitions. © 2018 The Author(s).InfectionsOrgan dysfunctionSepsisSeptic shock