Todorovic, J. (9533013000)J. (9533013000)TodorovicNesovic Ostojic, J. (15060276300)J. (15060276300)Nesovic OstojicOpric, D. (6506600388)D. (6506600388)OpricDundjerovic, D. (56515503700)D. (56515503700)DundjerovicBozic, V. (6701633314)V. (6701633314)BozicMarkovic, L. (57208790708)L. (57208790708)Markovic2025-06-122025-06-122014https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925228080&partnerID=40&md5=710c27ffe5560beb0f466caaa9466e4ahttps://remedy.med.bg.ac.rs/handle/123456789/8567Aim: Objective of the study was to clarify the role of apoptosis in the pathogenesis of lymphocytic thyroiditis (LT) and the existence of difference between Hashimoto's thyroiditis (HT) and LT. Methods: We evaluated levels of antithyroglobulin and antithyroperoxidase antibodies, the apoptosis by in situ Cell Death Detection-TUNEL and the expression of Bcl2 and Bax by immunohistochemistry in thyroid tissues from 16 patient with HT, 10 with LT and 10 with euthyroid goiter-EG (control group). Results: It was found that apoptosis of thyrocytes in HT (mean 3.05%, SD 1.29%) and LT (mean 2.70%, SD 1.17%) was statistically significantly higher than EG (mean 0.56%, SD 0.23%), but the difference in the percentage of thyrocytes between HT and LT was not statistically significant. In HT the percentage of apoptotic infiltrating lymphocytes (mean 0.59%, SD 0.23%) was smaller than in EG (mean 2.26%, SD 1.42%), but it showed no significant difference in comparison to LT. The expression of Bax in infiltrating lymphocytes in HT (mean 0.72%, SD 0.34%) was statistically significantly higher than LT (mean 0.11%, SD 0.06%). The level of thyroglobulin was lower in HT compared to LT (P<0.01) and compared to EG (P<0.01). The level of antithyroglobulin/antithyroperoxidase antibodies was higher in HT compared to LT (P<0.01) and compared to EG (P<0.01). There was no statistically significant difference in the level of thyroglobulin and level of antibodies between LT and EG. Conclusion: These results suppose that apoptosis represents one of significant mechanisms in the pathogenesis of both HT and LT and that LT probably differs from HT.ApoptosisAutoimmuneHashimoto diseaseThyroiditis